Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities

Journal of Medicinal Chemistry
D E BiererS R King

Abstract

Using an ethnobotanical approach in combination with in vivo-guided fractionation as a means for lead discovery, cryptolepine was isolated as an antihyperglycemic component of Cryptolepis sanguinolenta. Two syntheses of cryptolepine, including an unambiguous synthesis, are reported. The hydroiodide, hydrochloride, and hydrotrifluoromethanesulfonate (hydrotriflate) salts of cryptolepine were synthesized, and a comparison of their spectral properties and their in vitro activities in a 3T3-L1 glucose transport assay is made. Cryptolepine and its salt forms lower blood glucose in rodent models of type II diabetes. While a number of bioactivities have been reported for cryptolepine, this is the first report that cryptolepine possesses antihyperglycemic properties.

References

Dec 1, 1979·Journal of Pharmaceutical Sciences·K Boakye-Yiadom, S M Heman-Ackah
Mar 1, 1978·Journal of Pharmaceutical Sciences·D Dwuma-BaduD J Slatkin
Apr 1, 1994·Journal of Cardiovascular Pharmacology·A O Oyekan
Feb 1, 1996·Planta medica·K CimangaA J Vlietinck
Jan 1, 1996·Journal of Ethnopharmacology·O SilvaE Gomes

❮ Previous
Next ❯

Citations

Dec 31, 2002·Folia Microbiologica·S J R Chiuchetta, M A A Castro-Prado
Sep 22, 2000·Bioorganic & Medicinal Chemistry Letters·V CaprioS Neidle
Mar 12, 2002·Bioorganic & Medicinal Chemistry·Seth Y AblordeppeyCharles D Hufford
Apr 28, 1999·Bioorganic & Medicinal Chemistry·S Y AblordeppeyA Nimrod
Feb 28, 2001·Diabetes, Obesity & Metabolism·M J Reed, K A Scribner
Jun 20, 2012·Annals of Clinical Microbiology and Antimicrobials·Felix C Mills-RobertsonKingsley Badu
Mar 17, 2001·Environmental Health Perspectives·D S Fabricant, N R Farnsworth
Aug 8, 2012·Journal of Human Reproductive Sciences·Ayodeji F Ajayi, Roland E Akhigbe
Feb 18, 2011·Ghana Medical Journal·Michael S Tempesta
Apr 2, 2014·European Journal of Medicinal Chemistry·Katarzyna SidorykŁukasz Kaczmarek
Feb 18, 2016·Malaria Journal·Arnold D ForkuoMichael F Ofori
Mar 17, 2009·Phytotherapy Research : PTR·Olumayokun A OlajideColin W Wright
Jul 20, 2007·The Journal of Pharmacy and Pharmacology·Colin W Wright
Sep 10, 2016·The Journal of Organic Chemistry·Danqing ZhengJie Wu
Dec 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Harish C Pal, Santosh K Katiyar
Jul 19, 2018·Chemistry, an Asian Journal·Meng TangXiaowei Chang
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robert M GenganPalathurai S Mohan
May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andreia S P PereiraZeno Apostolides
Sep 15, 2012·Biological & Pharmaceutical Bulletin·Anna JarominArkadiusz Kozubek
Jan 1, 2017·Advances in Pharmacological Sciences·Newman OsafoOduro Kofi Yeboah
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katja S HåheimMagne O Sydnes
Jul 1, 2021·European Journal of Medicinal Chemistry·Yuqian ZhuHailong Zhang
Apr 9, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A O AnagaI U Asuzu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.