Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Frontiers in Aging Neuroscience
Devesh TewariAtanas G Atanasov

Abstract

Dementia is a clinical syndrome wherein gradual decline of mental and cognitive capabilities of an afflicted person takes place. Dementia is associated with various risk factors and conditions such as insufficient cerebral blood supply, toxin exposure, mitochondrial dysfunction, oxidative damage, and often coexisting with some neurodegenerative disorders such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD). Although there are well-established (semi-)synthetic drugs currently used for the management of AD and AD-associated dementia, most of them have several adverse effects. Thus, traditional medicine provides various plant-derived lead molecules that may be useful for further medical research. Herein we review the worldwide use of ethnomedicinal plants in dementia treatment. We have explored a number of recognized databases by using keywords and phrases such as "dementia", "Alzheimer's," "traditional medicine," "ethnopharmacology," "ethnobotany," "herbs," "medicinal plants" or other relevant terms, and summarized 90 medicinal plants that are traditionally used to treat dementia. Moreover, we highlight five medicinal plants or plant genera of prime importance and discuss the physiological eff...Continue Reading

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Citations

Feb 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ewelina Pogorzelska-NowickaAgnieszka Wierzbicka
Jul 26, 2018·Future Medicinal Chemistry·Nikolay T Tzvetkov, Atanas G Atanasov
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Oct 18, 2018·BMC Complementary and Alternative Medicine·Anchalee Prasansuklab, Tewin Tencomnao
Apr 27, 2019·Frontiers in Pharmacology·Devesh TewariAtanas G Atanasov
Jan 8, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jian-Ya YeChang-Sheng Ma
Sep 11, 2020·Environmental Science and Pollution Research International·Siju Ellickal NarayananBijo Mathew
Dec 7, 2018·Frontiers in Neuroscience·Andy Wai Kan YeungAtanas G Atanasov
Jul 3, 2019·Frontiers in Pharmacology·Devesh TewariGianina Crişan
Apr 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andy Wai Kan YeungAtanas G Atanasov
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Chiara MusilloFrancesca Cirulli
Apr 22, 2021·Degenerative Neurological and Neuromuscular Disease·Nafaa AlzobaidiMaaz Naqvi
Jul 10, 2021·Oxidative Medicine and Cellular Longevity·Md Sahab UddinMohamed M Abdel-Daim
Sep 8, 2021·Environmental Science and Pollution Research International·Rajeshwari SinghDevesh Tewari

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