Ethnopharmacological investigation of the diuretic and hemodynamic properties of native species of the Brazilian biodiversity

Journal of Ethnopharmacology
Thiago Buno Lima PrandoArquimedes Gasparotto Junior

Abstract

Although Echinodorus grandiflorus, Cuphea carthagenensis, and Phyllanthus tenellus infusions are used in Brazilian folk medicine due to their possible diuretic effect, none of these species was critically investigated as a diuretic drug. So, the aim of this study was to evaluate the possible acute diuretic activity of ethanol soluble fractions (ES) obtained from these species and assess the relationship between renal cortical blood flow and their antioxidant and hypotensive activity using normotensive Wistar rats. The preparation obtained from E. grandiflorus (ES-EG), C. carthagenensis (ES-CC), and P. tenellus (ES-PT) infusions was orally administered in a single dose to rats. Urine excretion rate, pH, density, conductivity and Na(+), K(+), Cl(-) and HCO3(-) contents were measured in the urine of saline-loaded animals. Concentration of electrolytes, total protein, urea, creatinine, and angiotensin converting enzyme (ACE) activity were evaluated in collected serum. The involvement of the renal cortical blood flow and antioxidative activity in the hypotensive and diuretic effects was also determined. Water and Na(+), Cl(-) and Na(+) excretion rates were significantly increased by ES-EG, while urinary bicarbonate excretion was red...Continue Reading

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Citations

Apr 30, 2016·Journal of Ethnopharmacology·Lorena Neris BarbozaArquimedes Gasparotto
Oct 12, 2018·Journal of Medicinal Food·Cleide Adriane Signor TirloniArquimedes Gasparotto Junior
Sep 29, 2020·Journal of Medicinal Food·Lislaine Maria KliderJane Manfron Budel

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