Ethnopharmacological Survey and Antisickling Activity of Plants Used in the Management of Sickle Cell Disease in Kikwit City, DR Congo

Evidence-based Complementary and Alternative Medicine : ECAM
Jules Munganga KitadiPius Tshimankinda Mpiana

Abstract

Sickle cell disease or drepanocytosis is the most known hemoglobin abnormality in the world. Recently, many medicinal plants used in the management of sickle cell disease in African traditional medicine have shown in vitro antisickling activity. This research study aims to document some Congolese plant species used in the management of sickle cell disease in Kikwit city and investigate their pharmacological property in vitro. A cross-sectional survey was done from June 2015 to March 2016 among 26 traditional healers in Kikwit city, Democratic Republic of Congo. Emmel test was used to assess in vitro antisickling activity. Habitat, morphological, biological types, phytogeographical distribution, local names, and used parts of these plant species were also determined. Obtained results show that 23 plant species belonging to 16 families are used. The leaves represent the most used part (70%). Antisickling investigation showed that aqueous extracts of 18 plants (78%) exhibit a change in the shape of a sickle cell into a normal one with a normalized rate of at least 70%, confirming the in vivo effect observed by traditional healers when used as herbal medicine traditionally in the management of sickle cell disease. The evaluation of...Continue Reading

References

Nov 23, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P T MpianaK N Ngbolua
Sep 6, 2012·Journal of Ethnopharmacology·M KatemoP R Koyange
Sep 10, 2015·Natural Products and Bioprospecting·Dorothée Dinangayi TshilandaPius Tshimankinda Mpiana
Apr 20, 2017·The New England Journal of Medicine·Frédéric B PielDavid C Rees

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BETA
electrophoresis

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Microcal Origin

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