Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Octavio A SantosMelissa E Murray

Abstract

Our primary goal was to examine demographic and clinicopathologic differences across an ethnoracially diverse autopsy-confirmed cohort of Alzheimer's disease cases. A retrospective study was conducted in the Florida Autopsied Multi-Ethnic cohort on 1625 Alzheimer's disease cases, including decedents who self-reported as Hispanic/Latino (n = 67), black/African American (n = 19), and white/European American (n = 1539). Hispanic decedents had a higher frequency of family history of cognitive impairment (58%), an earlier age at onset (median age of 70 years), longer disease duration (median of 12 years), and lower MMSE proximal to death (median of 4 points) compared with the other ethnoracial groups. Black decedents had a lower Braak tangle stage (stage V) and higher frequency of coexisting hippocampal sclerosis (21%); however, only hippocampal sclerosis differences survived adjustment for sex, age at onset, and disease duration. Neither Thal amyloid phase nor coexisting Lewy body disease differed across ethnoracial groups. Despite a smaller sample size, Hispanics demonstrated longer disease duration with Alzheimer's disease, but not greater lifespan. Neuropathologic differences across ethnoracial groups supported differences in ta...Continue Reading

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Citations

Aug 23, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Nobutaka SakaeDennis W Dickson
Aug 23, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Chia-Chen LiuGuojun Bu
Aug 18, 2020·Journal of Alzheimer's Disease : JAD·Andrea M KuraszMelissa J Armstrong
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Jul 6, 2021·Journal of Alzheimer's Disease : JAD·Brian DownerKenneth J Ottenbacher
Sep 30, 2021·Science Translational Medicine·Chia-Chen LiuGuojun Bu
Jan 28, 2022·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ranjan Duara, Warren Barker

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