Ethological analyses of crayfish behavior: a new invertebrate system for measuring the rewarding properties of psychostimulants

Behavioural Brain Research
Jules B Panksepp, Robert Huber

Abstract

Recent investigations in invertebrate neurobiology have opened up a new line of research into the basic behavioral, neurochemical and genomic alterations that accompany psychostimulant drug exposure. However, the extent to which such findings relate to changes in motivational and learning processes, such as those that typify drug addictions, remains unclear. The present study addressed this issue in the crayfish, Orconectes rusticus. The first set of experiments demonstrated that intramuscular injections of cocaine and amphetamine have robust and distinguishable effects on crayfish behavior. In the second part of the study, the reinforcing properties of psychostimulants were tested in a series of conditioned place preference experiments. Amphetamine and, to a lesser extent, cocaine were both found to serve as rewards when their intra-circulatory infusion was coupled to a distinct visual environment. The monoaminergic regulation of behavior has been extensively studied in decapod crustaceans and the present experiments demonstrated that (mammalian) drugs of abuse, capable of interfering with monoamine chemistry, are similarly rewarding to crayfish. Behavioral studies in crayfish can provide a complementary approach to using othe...Continue Reading

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Citations

Feb 3, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Robert Huber
Jan 16, 2008·BMC Molecular Biology·Hailing JinJian-Kang Zhu
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Jun 6, 2018·Frontiers in Physiology·Udita DattaRobert Huber
Feb 2, 2019·Frontiers in Neuroscience·Kenneth L Davis, Christian Montag
Nov 7, 2018·Perspectives on Behavior Science·Moira J van Staaden, Robert Huber
Dec 23, 2017·Frontiers in Physiology·Adam T ShipleyThomas I Nathaniel

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