Ethyl Acetate Fraction from Persimmon (Diospyros kaki ) Ameliorates Cerebral Neuronal Loss and Cognitive Deficit via the JNK/Akt Pathway in TMT-Induced Mice

International Journal of Molecular Sciences
Jong Min KimHo Jin Heo

Abstract

This study was conducted to assess the antioxidant capacity and protective effect of the ethyl acetate fraction from persimmon (Diospyros kaki) (EFDK) on H₂O₂-induced hippocampal HT22 cells and trimethyltin chloride (TMT)-induced Institute of Cancer Research (ICR) mice. EFDK had high antioxidant activities and neuroprotective effects in HT22 cells. EFDK ameliorated behavioral and memory deficits in Y-maze, passive avoidance and Morris water maze tests. Also, EFDK restored the antioxidant system by regulating malondialdehyde (MDA), superoxide dismutase (SOD) and reduced gluthathione (GSH), and the cholinergic system by controlling the acetylcholine (ACh) level and acetylcholinesterase (AChE) activity and expression. EFDK enhanced mitochondrial function by regulating reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP), and adenosine triphosphate (ATP). Ultimately, EFDK regulated the c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) pathway and apoptotic pathway by suppressing the expression of tumor necrosis factor-alpha (TNF-α), phosphorylated insulin receptor substrate 1 (IRS-1pSer), phosphorylated JNK (p-JNK), phosphorylated tau (p-tau), phosphorylated nuclear factor kappa-light-chain-enhancer o...Continue Reading

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Citations

Aug 2, 2019·Biological & Pharmaceutical Bulletin·Hang Thi Nguyet PhamKinzo Matsumoto
Jul 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara ThabitMichael Wink
Jun 19, 2019·Oxidative Medicine and Cellular Longevity·Bong Seok KwonHo Jin Heo
Dec 17, 2020·Journal of Food Biochemistry·Eun Jin ShinHo Jin Heo
Dec 15, 2020·Oxidative Medicine and Cellular Longevity·Jong Min KimHo Jin Heo

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Methods Mentioned

BETA
MDA
electrophoresis

Software Mentioned

SAS
ImageJ

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