Abstract
The role of fatty acid ethyl esters (FAEE), the nonoxidative ethanol metabolites, as mediators of alcohol-induced organ damage is increasingly being recognized. FAEE are detectable in the blood and in liver and adipose tissue after ethanol ingestion, and on that basis, FAEE can be used as markers of ethanol intake. In this study, 10 samples of human brain were collected at autopsy at the Massachusetts Medical Examiner's Office and analyzed for FAEE. FAEE were isolated and quantified as mass per gram of wet weight. The blood ethanol level was also obtained in each case along with the other drugs detected in routine postmortem toxicology screening tests. Ethyl arachidonate was the predominant FAEE species in the brain, representing up to 77.4% of total FAEE in the brain. The percent age of ethyl arachidonate of the total FAEE in the brain was significantly higher than what has been found in all other organs and tissues previously analyzed. Linoleate, the precursor of arachidonate, was a poor substrate for FAEE synthesis, as the percentage of ethyl linoleate of the total FAEE content was extremely low. Thus, this reflects preferred incorporation of arachidonate into newly synthesized FAEE in the brain. Since arachidonate is derive...Continue Reading
References
Oct 1, 1992·Drug and Alcohol Dependence·O DuffyB E Leonard
Jul 1, 1992·Alcohol·S V PirozhkovV Bernhard
Jul 9, 1991·Biochimica Et Biophysica Acta·J I MacDonald, H Sprecher
Jan 31, 1986·Science·E A Laposata, L G Lange
Apr 1, 1973·Zeitschrift Für Klinische Chemie Und Klinische Biochemie·P LeschF W Schmidt
Feb 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M LaposataJ E Brown
Jan 1, 1994·Lipids·E L LienC F Kuhlman
Jan 1, 1993·Alcohol·M G Subramanian, R T Savoy-Moore
Oct 9, 1996·JAMA : the Journal of the American Medical Association·K M DoyleM Laposata
Oct 1, 1996·Journal of Neurochemistry·H U ShettyA D Purdon
Apr 21, 1999·Progress in Lipid Research·M Laposata
Jun 24, 1999·Lipids·L AbedinA J Sinclair
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·M LaposataA A Nanji
May 8, 2001·Lipids·Z FuA J Sinclair
Aug 2, 2001·Journal of Molecular Neuroscience : MN·A A Spector
May 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·D S GOODMAN, D DEYKIN
Citations
Dec 29, 2013·Acta Neuropathologica·Suzanne M de la Monte, Jillian J Kril
May 30, 2013·Drug Metabolism Reviews·Irene ZelnerGideon Koren
Jul 5, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yin DuanRussell A Nicholson
Oct 19, 2006·Medical Hypotheses·Marie Cecchini, Vincent LoPresti
Jun 20, 2006·Forensic Science International : Synergy·Fredrik C Kugelberg, Alan Wayne Jones