Ethyl-cellulose rumen-protected methionine alleviates inflammation and oxidative stress and improves neutrophil function during the periparturient period and early lactation in Holstein dairy cows

Journal of Dairy Science
Fernanda BatistelJ J Loor

Abstract

The periparturient period is the most critical phase in the productive cycle of dairy cows and is characterized by impairment of the immune system. Our objective was to evaluate the effect of feeding ethyl-cellulose rumen-protected methionine (RPM) starting at d -28 from expected parturition through 60 d in milk on biomarkers of inflammation, oxidative stress, and liver function as well as leukocyte function. Sixty multiparous Holstein cows were used in a block design and assigned to either a control or the control plus ethyl-cellulose RPM (Mepron, Evonik Nutrition & Care GmbH). Mepron was supplied from -28 to 60 d in milk at a rate of 0.09% and 0.10% dry matter during the prepartum and postpartum period. That rate ensured that the ratio of Lys to Met in the metabolizable protein was close to 2.8:1. Blood samples from 15 clinically healthy cows per treatment were collected at d -30, -14, 1, 7, 21, 30, and 60 and analyzed for biomarkers of liver function, inflammation, and oxidative stress. Neutrophil and monocyte function in whole blood was measured in vitro at -14, 1, 7, 21, and 30 d in milk. The statistical model included the random effect of block and fixed effect of treatment, time, and its interaction. Compared with contro...Continue Reading

References

Feb 16, 1991·The Veterinary Record·J G SkinnerL Roberts
Apr 1, 1996·Journal of Dairy Science·T R OvertonJ H Clark
Mar 1, 1960·Journal of Clinical Pathology·J A OWENJ HOBAN
Feb 28, 2004·The Journal of Nutrition·Guoyao WuNancy D Turner
Sep 18, 2004·Veterinary Research Communications·G BertoniF Piccioli-Cappelli
May 17, 2006·The Journal of Nutrition·John T Brosnan, Margaret E Brosnan
May 17, 2006·The Journal of Nutrition·Robert F Grimble
Jun 20, 2006·Veterinary Clinical Pathology·Marie-France HumbletJean-Marie Godeau
Mar 8, 2008·The Veterinary Journal·Jerry W Spears, William P Weiss
Jul 25, 2008·Nature·Ruslan Medzhitov
Nov 26, 2008·Veterinary Immunology and Immunopathology·Lorraine M Sordillo, Stacey L Aitken
Dec 21, 2010·IUBMB Life·Jörg R AschenbachGregory B Penner
Feb 8, 2011·Biochimica Et Biophysica Acta·Jürgen SchellerStefan Rose-John
Dec 27, 2011·Research in Veterinary Science·E TrevisiG Bertoni
Jan 27, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing YanYusen Liu
Apr 29, 2014·Molecular Cell·Raj Chovatiya, Ruslan Medzhitov
Jul 27, 2015·Journal of Dairy Science·B J BradfordA J Carpenter
Nov 26, 2015·Antioxidants & Redox Signaling·Kate CampbellMarkus Ralser
Feb 3, 2016·Journal of Dairy Science·L M Sordillo

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Citations

Jun 5, 2019·Animals : an Open Access Journal From MDPI·Qi MouPeng-Fei Huang
Oct 2, 2019·Animal : an International Journal of Animal Bioscience·L Y DingJ Zhang
Apr 13, 2020·Journal of Dairy Science·J W McFaddenH M White
Aug 19, 2020·Journal of Animal Science·Danielle N ColemanJuan J Loor
Dec 24, 2019·Journal of Animal Science and Biotechnology·Khuram ShahzadJuan J Loor
Aug 17, 2020·Animals : an Open Access Journal From MDPI·Valerio BronzoBianca Castiglioni
Aug 31, 2020·Journal of Animal Science and Biotechnology·Vincenzo LopreiatoErminio Trevisi
Dec 16, 2020·BMC Veterinary Research·Mona H AhmedHans-Joachim Schuberth
Mar 10, 2021·Journal of Dairy Science·Fabiana F CardosoMarina A C Danes

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