Ethyl-EPA in Alzheimer's disease--a pilot study

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Paul F BostonCrispin N Bennett

Abstract

This pilot study of ethyl-eicosapentaenoate (ethyl-EPA) in the treatment of Alzheimer's disease aimed to estimate the magnitude of any change in measures of cognition during a 12-week treatment period. A simple linear design was used in which each patient had a baseline period of 12 weeks without treatment, followed by 12 weeks' treatment with ethyl-EPA. Blood samples were taken both before and after the treatment period to measure erythrocyte membrane fatty acids. Assessments comprised cognitive measures and visual analogue ratings of overall assessment of functioning. There was little difference between treatment and baseline periods in the rate of decline of efficacy measures, except for a small improvement in carer's visual analogue rating (P=0.02). It was concluded that it is unlikely there were any clinically important treatment effects of ethyl-EPA on cognition during the 12-week treatment period. A longer treatment period may be necessary to demonstrate efficacy of ethyl-EPA in this disorder.

Citations

Jun 11, 2008·Neuromolecular Medicine·S C Dyall, A T Michael-Titus
Dec 19, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Tommy Cederholm, Jan Palmblad
Jul 12, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mélanie Plourde, Stephen C Cunnane
May 16, 2012·Advances in Nutrition·Pedro Luis Prior, José Carlos Fernandes Galduróz
Sep 24, 2011·The Journal of Clinical Psychiatry·M Elizabeth SubletteJ John Mann
Jul 31, 2013·European Journal of Nutrition·Ane Otaegui-ArrazolaPablo Martínez-Lage
Oct 10, 2013·The Proceedings of the Nutrition Society·Marie HennebelleStephen C Cunnane
Feb 5, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Philip ScheltensAlexander Kurz
Apr 14, 2009·Progress in Lipid Research·S C CunnaneP Barberger-Gateau
May 20, 2008·Journal of Affective Disorders·Ticyana Moralez da SilvaAnete Curte Ferraz
Aug 15, 2006·Neuroscience Research·Susumu KotaniTetsumori Yamashima
Mar 31, 2009·Journal of the American Dietetic Association·Natalie D RiedigerMohammed H Moghadasian
Jul 11, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Erika FreemantleStephen C Cunnane
May 6, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Giuseppe Astarita, Daniele Piomelli
Feb 7, 2012·Neurobiology of Aging·Graham MazereeuwNathan Herrmann
Jul 19, 2016·Critical Reviews in Biotechnology·Michio HashimotoHiroyuki Arai
Mar 10, 2016·Journal of Clinical Medicine·Stanislaw Klek
Oct 19, 2017·The Proceedings of the Nutrition Society·P C Calder
May 29, 2009·The American Journal of Clinical Nutrition·Edeltraut KrögerDanielle Laurin
Sep 17, 2016·Advances in Nutrition·Jessay Gopuran DevassyHarold M Aukema
Oct 16, 2019·Frontiers in Immunology·Xiaoxi LiAllan Z Zhao
Oct 27, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Martijn C de WildeJohn W Sijben
Sep 10, 2008·The American Journal of Clinical Nutrition·Cécilia SamieriPascale Barberger-Gateau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.