Ethyl glucuronide and ethyl sulfate

Advances in Clinical Chemistry
Natalie E Walsham, Roy A Sherwood

Abstract

Alcohol misuse is associated with significant morbidity and mortality. Although clinical history, examination, and the use of self-report questionnaires may identify subjects with harmful patterns of alcohol use, denial or under-reporting of alcohol intake is common. Existing biomarkers for detecting alcohol misuse include measurement of blood or urine ethanol for acute alcohol consumption, and carbohydrate-deficient transferrin and gamma-glutamyl transferase for chronic alcohol misuse. There is a need for a biomarker that can detect excessive alcohol consumption in the timeframe between 1 day and several weeks. Ethyl glucuronide (EtG) is a direct metabolite of ethanol detectable in urine for up to 90 h and longer in hair. Because EtG has high specificity for excess alcohol intake, it has great potential for use in detecting "binge" drinking. Using urine or hair, this noninvasive marker has a role in a variety of clinical and forensic settings.

Citations

Sep 19, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hélène Donnadieu-RigoleGeorges-Philippe Pageaux
Sep 14, 2019·Angewandte Chemie·Justin LangePauline Poinot
Mar 16, 2017·Alcoholism, Clinical and Experimental Research·Ludmila N BakhirevaRajesh C Miranda
Apr 14, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chloé HugbartThomas Gicquel
Aug 7, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Julia M GrottenthalerChristoph P Berg
Feb 27, 2021·Archives of Pathology & Laboratory Medicine·Christine L H SnozekMatthew D Krasowski

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