Ethyl Glucuronide as a Long-term Alcohol Biomarker in Fingernail and Hair. Matrix Comparison and Evaluation of Gender Bias

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Richard PaulA Corbin

Abstract

This work aimed to assess the performance of hair and fingernail ethyl glucuronide (EtG) measurement for use as a biomarker of alcohol consumption in persons with known drinking history across a range of drinking behaviours. EtG concentrations were assessed from the hair and fingernails of 50 study participants. Alcohol consumption of the previous 90 days was assessed by participant interview using the alcohol timeline follow-back method. EtG concentration was determined using LC-MS-MS using a method which was validated and accredited to ISO/IEC 17025 standards. There was significant correlation between alcohol consumption and EtG concentrations found in hair and fingernail samples across the study group (n = 50). From participants testing positive for EtG (male n = 14, female n = 13) no significant difference was found between male and female EtG levels in either hair or fingernails. Across all participants there was no significant difference in hair or fingernail EtG concentration between male (n = 23) and females (n = 27). Our results support the use of EtG to indicate alcohol consumption over the previous 90 days, or ~3 months as is the normal practice in hair analysis. The results confirm that fingernails can be a useful a...Continue Reading

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Citations

Mar 24, 2020·Journal of the American Heart Association·Inge A T van de LuitgaardenJoline W J Beulens
Nov 19, 2020·Journal of Analytical Toxicology·Xiaomin ChenYan Jiang
May 29, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Setor K KunutsorStephan J L Bakker
Jan 21, 2020·Nano-micro Letters·Ramin BoroujerdiRichard Paul
Aug 2, 2021·Forensic Science International : Synergy·María Cobo-GolpeElena Lendoiro
Nov 3, 2021·Nature Reviews. Gastroenterology & Hepatology·Juan Pablo ArabVijay H Shah

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