Ethyl Pyruvate Induces Tolerogenic Dendritic Cells

Frontiers in Immunology
Neda DjedovićĐorđe Miljković

Abstract

Dendritic cells (DC) are professional antigen presenting cells that have a key role in shaping the immune response. Tolerogenic DC (tolDC) have immuno-regulatory properties and they are a promising prospective therapy for multiple sclerosis and other autoimmune diseases. Ethyl pyruvate (EP) is a redox analog of dimethyl fumarate (Tecfidera), a drug for multiple sclerosis treatment. We have recently shown that EP ameliorates experimental autoimmune encephalomyelitis, a multiple sclerosis murine model. Here, we expanded our study to its tolerogenic effects on DC. Phenotypic analysis has shown that DC obtained from mice or humans reduce expression of molecules required for T cell activation such as CD86, CD83, and HLA-DR under the influence of EP, while CD11c expression and viability of DC are not affected. Furthermore, EP-treated DC restrain proliferation and modulate cytokine production of allogeneic lymphocytes. These results demonstrate that EP has the ability to direct DC toward tolDC.

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Citations

Sep 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ivan KoprivicaIvana Stojanović
Feb 12, 2020·International Immunopharmacology·Urban Švajger, Primož J Rožman
Nov 11, 2020·Chemico-biological Interactions·Deepti SharmaHimanshu Ojha
May 8, 2021·Cellular & Molecular Immunology·M J MansillaE M Martínez-Cáceres
Oct 14, 2021·Journal of Leukocyte Biology·Xiaoqi ZhouPing Lei

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Methods Mentioned

BETA
density gradient centrifugation
FCS
flow cytometry
ELISAs
ELISA

Software Mentioned

FACSDiva
FlowJo

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