PMID: 15377894Sep 21, 2004Paper

Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis

Shock
Runkuan YangMitchell P Fink

Abstract

Ethyl pyruvate has been shown to ameliorate liver injury and decrease expression of several proinflammatory cytokines when used to treat mice with hemorrhagic shock or alcoholic hepatitis. Herein we sought to determine whether delayed treatment with ethyl pyruvate dissolved in a Ringer's-type balanced salt solution--Ringer's ethyl pyruvate solution (REPS)--would be beneficial in a murine model of common bile duct ligation (CBDL)-induced liver injury. Male C57BL/6 mice were subjected to a sham (n = 6) procedure or CBDL (n = 27). Twenty-four hours after operation, mice subjected to CBDL were randomized to receive treatment with either REPS (40 mg/kg of ethyl pyruvate per dose) or Ringer's lactate solution (RLS) every 8 h over a 72 h period. Compared with sham-treated controls, CBDL in RLS-treated mice was associated with histological evidence of hepatocellular necrosis as well as significant increases in the plasma concentrations of alanine aminotransferase and total bilirubin. Relative to sham-treated controls, CBDL in RLS-treated mice also was associated with increased hepatic lipid peroxidation and increased hepatic expression of transcripts for TNF, IL-6, and iNOS. All of these changes were significantly attenuated by delayed...Continue Reading

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Citations

Feb 25, 2009·Critical Care Medicine·Bolin CaiLusi Ulloa
Jun 11, 2009·The Journal of Trauma·Bolin CaiLuis Ulloa
Jan 18, 2012·Critical Care : the Official Journal of the Critical Care Forum·Runkuan YangJyrki Tenhunen
Jun 27, 2009·Expert Opinion on Investigational Drugs·Xuemei LiPeter Q Eichacker
Jul 16, 2008·Free Radical Biology & Medicine·Hong Sook KimMyung-Hee Chung
Nov 26, 2008·The Journal of Surgical Research·Runkuan YangMitchell P Fink
Jun 19, 2007·The Journal of Surgical Research·Ben M TsaiDaniel R Meldrum
Mar 16, 2007·Biomedical Chromatography : BMC·Filip MajerFrantisek Smíd
Mar 30, 2007·Journal of Internal Medicine·M P Fink
Jul 4, 2006·Nutrition·Undurti N Das
Dec 26, 2012·Journal of Hepatology·Rafaz HoqueWajahat Mehal
Nov 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Srinivasan Dasarathy
Oct 22, 2014·Molecular Medicine·Joo-Hyun ShinJa-Kyeong Lee
Dec 17, 2016·Journal of Inflammation·Runkuan YangTor Inge Tonnessen
Nov 2, 2007·Radiation Research·Michael EpperlyJoel S Greenberger
Dec 2, 2011·American Journal of Physiology. Renal Physiology·Kyung Don JuKook-Hwan Oh

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