PMID: 8597649Nov 1, 1995Paper

Ethylene glycol monomethyl ether effects on health and reproduction in male rabbits

Reproductive Toxicology
R H FooteJ Li

Abstract

Male Dutch rabbits were weighed and randomly assigned within each weight group to five groups of six animals each (plus one more in the highest dose group). They received 0, 12.5, 25.0, 37.5, or 50.0 mg of ethylene glycol monomethyl ether (EGME) per kg of body weight in the drinking water 5 d/week for 12 weeks. Feed and water consumption were monitored daily and body weight weekly. All animals consumed the water and feed, maintained body weight, and were in good health throughout the experiment. Semen was collected twice weekly for 12 weeks, and 96% of the ejaculates were obtained. By weeks 6 and 9, most males in groups receiving 50.0 or 37.5 mg of EGME per kg were oligospermic. Only minor changes in other characteristics of sperm obtained from treated animals were found, as measured by computer-assisted sperm analysis. Fertility of the males still producing sufficient sperm during week 12 to use for insemination was tested with 96 does producing 2839 oocytes, and fertility of treated males (41%) was not lower (P > 0.05) than 47% in controls. At necropsy, all vital organs were grossly normal, with no notable histopathology. However, the groups of animals receiving 37.5 and 50 mg of EGME per kg of body weight produced fewer sper...Continue Reading

References

Jan 1, 1992·Reproductive Toxicology·R E ChapinS Schrader
Nov 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J WilliamsR E Chapin
May 1, 1986·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R H FooteM E Simkin
Jul 1, 1986·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B H ScortichiniK S Rao
Jun 1, 1983·Toxicology·B D Hardin
Jan 1, 1982·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R P Amann
Jul 1, 1983·Toxicology and Applied Pharmacology·P M FosterS D Gangolli
Jan 1, 1983·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R R MillerM J McKenna
May 1, 1994·Human & Experimental Toxicology·R G Browning, S C Curry
Oct 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·V L SlottS D Perreault
Jul 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R E ChapinS R Kennedy
Jun 1, 1964·Journal of Reproduction and Fertility·P J BREDDERMANA M YASSEN

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Citations

Dec 2, 2000·Reproductive Toxicology·R H Foote, E W Carney
Mar 19, 2003·Reproductive Toxicology·Petros YpsilantisConstantinos Simopoulos
Jan 1, 1997·Reproductive Toxicology·W E Berndtson, R H Foote
Dec 13, 2006·Environmental Research·Audrey M CummingsRobert J Kavlock
Jun 14, 2000·Critical Reviews in Toxicology·G Johanson

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