Ethylene-induced stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 is mediated by proteasomal degradation of EIN3 binding F-box 1 and 2 that requires EIN2 in Arabidopsis.

The Plant Cell
Fengying AnHongwei Guo

Abstract

Plant responses to ethylene are mediated by regulation of EBF1/2-dependent degradation of the ETHYLENE INSENSITIVE3 (EIN3) transcription factor. Here, we report that the level of EIL1 protein is upregulated by ethylene through an EBF1/2-dependent pathway. Genetic analysis revealed that EIL1 and EIN3 cooperatively but differentially regulate a wide array of ethylene responses, with EIL1 mainly inhibiting leaf expansion and stem elongation in adult plants and EIN3 largely regulating a multitude of ethylene responses in seedlings. When EBF1 and EBF2 are disrupted, EIL1 and EIN3 constitutively accumulate in the nucleus and remain unresponsive to exogenous ethylene application. Further study revealed that the levels of EBF1 and EBF2 proteins are downregulated by ethylene and upregulated by silver ion and MG132, suggesting that ethylene stabilizes EIN3/EIL1 by promoting EBF1 and EBF2 proteasomal degradation. Also, we found that EIN2 is indispensable for mediating ethylene-induced EIN3/EIL1 accumulation and EBF1/2 degradation, whereas MKK9 is not required for ethylene signal transduction, contrary to a previous report. Together, our studies demonstrate that ethylene similarly regulates EIN3 and EIL1, the two master transcription facto...Continue Reading

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Citations

Mar 26, 2013·Plant Cell Reports·Feifei WangChun-Hai Dong
Oct 26, 2012·Plant Molecular Biology·Haoshan Zhang, Chunjiang Zhou
Jul 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ziqiang ZhuHongwei Guo
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Apr 27, 2013·Molecular Plant-microbe Interactions : MPMI·Keisuke MaseHirofumi Yoshioka
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Jan 3, 2012·Journal of Plant Physiology·María Amparo Asensi-FabadoSergi Munné-Bosch

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