PMID: 9174443Apr 1, 1997Paper

Ethylene oxide does not extinguish the osteoinductive capacity of demineralized bone. A reappraisal in rats

Acta Orthopaedica Scandinavica
Q ZhangC Delloye

Abstract

We examined the influence of ethylene oxide (EO) and gamma irradiation on the osteoinductive capacity of demineralized bone. Demineralized bone powder prepared from Wistar rats was exposed to EO (55 degrees C or 40 degrees C) or gamma irradiation (25 KGy) or was preserved in ethanol. Sterilely-prepared bones served as controls. The powder was packed in a gelatin capsule and implanted for 6 weeks in muscles of 6-week-old female rats. Exposure of demineralized bone particles to EO 55 degrees C resulted in an almost complete loss of osteoinductivity. Irradiated bones lost about 40% of their osteoinductive capacity, while sterilization with EO at 40 degrees C resulted in only a slight alteration of the osteoinductivity, as assessed by the recovered weight ratio, calcium content, alkaline phosphatase activity measurements and histomorphometry. Ethanol treatment had no influence on the new bone yield when compared to controls. As EO exposure at 40 degrees C is a true sterilization procedure, it can be recommended in a clinical setting for its small effect on osteoinductive capacity as assessed experimentally in rats.

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Citations

Jun 5, 2007·Journal of Materials Science. Materials in Medicine·Jason HoddeChad Johnson
Jul 17, 2001·Journal of Periodontology·UNKNOWN Committee on Research, Science and Therapy of the American Academy of Periodontology.
Apr 17, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Nobuhiro KakuTakehiko Torisu
Sep 3, 1999·The Orthopedic Clinics of North America·T BoyceN Scarborough
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Cahir A McDevittRochelle M Cutrone
May 29, 1998·Acta Orthopaedica Scandinavica·P Aspenberg, S B Lindqvist
Jun 1, 2001·Journal of Periodontology·UNKNOWN Committee on Research, Science and Therapy of the American Academy of Periodontology
May 4, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·T PekkarinenP Jalovaara

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