PMID: 7082461Apr 1, 1982Paper

Ethylenediamine as a specific releasing agent of gamma-aminobutyric acid in rat striatal slices

Journal of Neurochemistry
H G LloydTrevor W Stone

Abstract

Following incubation with [14C]gamma-aminobutyric acid (GABA) or [3H]dopamine, slices of rat striatum were superfused with media containing 36 mM K+ or ethylenediamine (EDA), 1 or 5 mM. Both K+ and EDA induced a release being largely Ca2+-dependent, while the EDA-induced release was not. Whereas K+ also evoked a Ca2+-dependent release of [3H]dopamine, EDA evoked no release of dopamine. EDA may therefore have potential as a specific GABA releasing agent.

References

Aug 31, 1978·Nature·P R Mitchell, I L Martin
Jan 1, 1966·The Biochemical Journal·J L Mangan, V P Whittaker
May 29, 1981·Neuroscience Letters·M N PerkinsTrevor W Stone
Jan 1, 1965·British Medical Bulletin·K A ELLIOTT

Citations

Oct 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·C A MaggiA Meli
Nov 4, 1986·European Journal of Pharmacology·S L ErdöL Szporny
Feb 24, 1987·European Journal of Pharmacology·J Ong, D I Kerr
Feb 20, 1990·European Journal of Pharmacology·A KrantisA McKay
Aug 1, 1983·Respiration Physiology·F L EldridgeJ P Kiley
Jan 1, 1985·General Pharmacology·E Contreras, L Tamayo
Aug 1, 1989·Journal of Autonomic Pharmacology·A J BarbierR A Lefebvre
Nov 1, 1982·British Journal of Pharmacology·P F Morgan, Trevor W Stone

Related Concepts

Ethylenediamine, 3H-labeled cpd
Lentiform Nucleus Structure
Ethylenediamines
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Potassium
August Rats

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