Abstract
Parabens are generally used as preservatives in foods, pharmaceuticals, and various other commercial products. Among them, ethylparaben has weaker estrogenic characteristics than endogenous estrogen. However, growing evidence indicates that ethylparaben has an adverse effect on various human tissues. Here, we investigated whether ethylparaben induces cell death by affecting cell viability, cell proliferation, cell cycle, and apoptosis using the human placenta cell line BeWo. Ethylparaben significantly decreased cell viability in a dose-dependent manner. It caused cell cycle arrest at sub-G1 by reducing the expression of cyclin D1, whereas it decreased the cell proportion at the G0/G1 and S phases. Furthermore, we verified that ethylparaben induces apoptotic cell death by enhancing the activity of Caspase-3. Taken together, our results suggest that ethylparaben exerts cytotoxic effects in human placental BeWo cells via cell cycle arrest and apoptotic pathways.
References
Feb 7, 2001·Pharmacology & Toxicology·K L PedersenP Bjerregaard
Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T OkuboI Kano
Jan 28, 2004·Journal of Applied Toxicology : JAT·P D DarbreG S Pope
Apr 19, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M G SoniG A Burdock
Aug 16, 2005·Critical Reviews in Toxicology·Robert GoldenGuenter Vollmer
Feb 18, 2006·Free Radical Research·Chiho NishizawaToshihiko Ozawa
Dec 23, 2006·Environmental Health Perspectives·Xiaoyun YeAntonia M Calafat
Jan 16, 2008·International Journal of Andrology·Nadeem Rezaq JanjuaAnna-Maria Andersson
May 20, 2008·Journal of Applied Toxicology : JAT·Philippa D Darbre, Philip W Harvey
Jul 24, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Camilla TaxvigChristine Nellemann
Aug 5, 2010·Mutation Research·José Manuel Pérez MartínMaría José Hazen
Jun 4, 2013·The Science of the Total Environment·Sungeun KangKyungho Choi
Aug 6, 2013·Environmental Health Perspectives·Kristen W SmithRuss Hauser
Mar 25, 2014·Environment International·Dorota BłędzkaWojciech Wąsowicz
Dec 3, 2014·Journal of Chromatography. a·F Vela-SoriaA Navalón
Sep 15, 2015·Environment International·Benny F G PyckeRolf U Halden
Dec 8, 2015·Journal of Pharmaceutical and Biomedical Analysis·Abdelmonaim AzzouzEvaristo Ballesteros
Dec 21, 2016·Journal of Applied Toxicology : JAT·F FinotR M'Kacher
Aug 3, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Divya DubeyRatan Singh Ray
Sep 28, 2017·Physiological Research·L KolatorovaL Starka
Jan 11, 2018·Environmental Toxicology·Changwon YangGwonhwa Song
Jan 13, 2018·Chromosoma·Xiaoming Sun, Paul D Kaufman
Mar 8, 2019·Environment International·Wenyu LiuShunqing Xu
Citations
Jun 21, 2021·The Science of the Total Environment·Nathaniel B BolujokoOlumide D Olukanni
Jul 16, 2021·Animal Cells and Systems·Munkhzaya ByambaragchaaKwan-Sik Min
Jul 16, 2021·Animal Cells and Systems·Joon-Cheol KwonTakahiko Horiuchi