PMID: 3773532Oct 1, 1986Paper

Ethynylestradiol alters lipid composition and phosphatidylethanolamine metabolism in red blood cells

Journal of Steroid Biochemistry
J Le Petit-ThéveninJ Boyer

Abstract

Treatment of female rats with ethinylestradiol at a dose of 60 micrograms/rat, daily for 21 days, produced marked changes in red blood cell lipids. Cholesterol was decreased by 22% and total phospholipids were increased by 13%, resulting in a 31% decrease in the cholesterol to phospholipid ratio. The mass distribution of phosphatidylcholine and phosphatidylethanolamine relative to total phospholipids was unchanged. Whereas control red cells incorporated preferentially fatty acids in phosphatidylcholine, ethinylestradiol stimulated their incorporation specifically in phosphatidylethanolamine, where increases occurred with palmitic acid (+75%), oleic acid (+68%) and arachidonic acid (+31%). Incorporation in phosphatidylcholine was unaffected with any of the 3 fatty acids. The stimulation of fatty acid incorporation in phosphatidylethanolamine is likely to reflect an estrogen-dependent increase in turnover rate of fatty acids in this phospholipid. Such alterations in lipid composition and fatty acid incorporation in red cell phospholipids may have significant effects on membrane function.

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Citations

Feb 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T S ThurmondP S Coogan
May 10, 2017·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Albe C SwanepoelEtheresia Pretorius
Sep 1, 1991·The American Journal of Physiology·J Le Petit-TheveninJ Boyer

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