Etiologic causes of late osteocutaneous free flap failures in oral cavity cancer reconstruction

The Laryngoscope
Chad A ZenderJames J Jaber

Abstract

To evaluate perioperative complications in a homogeneous cohort undergoing microvascular osteocutaneous free flap (OCFF) reconstruction following segmental mandibulectomy for advanced oral cancer and to identify the causes of late OCFF failures. Retrospective chart review. The records of 65 adults who underwent a segmental mandibulectomy for primary oral cavity cancer followed by single-stage reconstruction OCFF were reviewed. Early and late complications were identified and their associations to patients' independent variables and to each other were analyzed to assess etiologic causes of late OCFF failure. The incidence of early and late complications mirrored each another at 29%, and a 95% early-success rate was achieved. An early complication did predict an early infection (odds ratio [OR], 63.3; 95% confidence interval [CI], 6.8-585.3). Furthermore, an early perioperative infection impacted the incidence of late complications (OR, 4.8; 95% CI, 1.3-18.3), and moreover severely impacted the incidence of osteomyelitis/osteoradionecrosis (OR, 8.8; 95% CI, 1.8-41.9) and late failures (OR, 12.8; 95% CI, 1.9-84.5). Mandibular reconstruction following segmental mandibulectomy provides immediate restoration but is often plagued with...Continue Reading

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Citations

Jan 14, 2016·The Lancet Oncology·James S BrownRichard Shaw
Jan 10, 2017·Microsurgery·Kate ClancyChad A Zender
Jan 10, 2017·The British Journal of Oral & Maxillofacial Surgery·J S BrownA Schache
Jun 30, 2018·Microsurgery·Jessica PrasadAnthony C Nichols
Mar 25, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Brian SwendseidJoseph M Curry
Jul 24, 2018·Ear, Nose, & Throat Journal·David FornerRobert D Hart
Nov 13, 2020·The Laryngoscope·Chelsea S HamillThomas O'Toole
Mar 20, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jonathan D WestNiels C Kokot
Mar 30, 2021·Bio-medical Materials and Engineering·Olivia T ChengChad A Zender
Aug 14, 2021·Current Opinion in Otolaryngology & Head and Neck Surgery·Samuel J RubinJohn E Hanks

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