Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
J ShodaN Tanaka

Abstract

Intrahepatic calculi, highly prevalent in the Far East, including Japan, are characterized clinically by chronic proliferative cholangitis with frequent stone recurrences. Intrahepatic calculi consist of 2 groups, i.e., brown pigment stones, including a high cholesterol content, and cholesterol stones, with the former predominating. To gain insights into the pathogenesis of intrahepatic calculi, cholesterol and bile acid biosynthesis, as well as alterations in intracellular transport and/or canalicular secretion of phospholipid and bile acid were investigated in liver of patients with intrahepatic calculi. Enzyme activities of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase were increased (12.8 +/- 1.9 pmol/min/mg protein, mean +/- SEM vs. 5.5 +/- 0.4 in controls; P < .01) and cholesterol 7 alpha-hydroxylase activities were decreased (1.3 +/- 0.4 vs. 4.9 +/- 0.6; P < .01) in liver specimens of patients with brown pigment stones. In addition, messenger RNA (mRNA) levels of multidrug resistance P-glycoprotein 3 (MDR3 Pgp) and phosphatidylcholine transfer protein (PCTP) were markedly low in the liver specimens compared with the levels in specimens of control subjects, gallbladder stone patients, and patients with obstruc...Continue Reading

Citations

Jun 12, 2004·Current Gastroenterology Reports·David Q-H Wang, Nezam H Afdhal
Jan 29, 2008·Current Treatment Options in Gastroenterology·Shikha S Sundaram, Ronald J Sokol
Aug 2, 2003·Gastroenterology·Olivier RosmorducRaoul Poupon
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Junichi ShodaNaomi Tanaka
Oct 1, 2003·Pathology International·Tadashi TeradaIsao Osada
Oct 13, 2006·Current Opinion in Gastroenterology·Michael Trauner, James L Boyer
Mar 2, 2013·Current Opinion in Gastroenterology·Marcin KrawczykFrank Lammert
Jun 15, 2007·Orphanet Journal of Rare Diseases·Olivier Rosmorduc, Raoul Poupon
Nov 20, 2008·Journal of Lipid Research·David Q-H WangMartin C Carey
Apr 18, 2013·Insights Into Imaging·Julie BenzimraLionel Arrivé
Jun 12, 2010·Gastroentérologie Clinique Et Biologique·R PouponO Rosmorduc
May 19, 2010·Gastroenterology Clinics of North America·Helen H WangDavid Q H Wang
May 15, 2007·Biochimica Et Biophysica Acta·Keishi KannoDavid E Cohen
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Junichi ShodaYuichi Sugiyama
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frank LammertMartin C Carey
Jun 2, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Junichi ShodaHiroshi Suzuki
May 4, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ekaterina Y ShishovaDavid E Cohen
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Elisabeth KronesPeter Fickert
Jun 29, 2015·Annals of Diagnostic Pathology·Mukul VijMohamed Rela
Oct 22, 2013·Molecular Aspects of Medicine·Marion J PollheimerBruno Stieger
Apr 29, 2016·Nature Reviews. Disease Primers·Frank LammertDavid Q-H Wang
Aug 31, 2006·Journal of Lipid Research·Wen-Jun WangDavid E Cohen
Jan 6, 2016·World Journal of Gastroenterology : WJG·Hyo Jung KimYoung-Tae Bak
Aug 21, 2007·The Journal of Biological Chemistry·Keishi KannoDavid E Cohen
Mar 29, 2003·Physiological Reviews·Michael Trauner, James L Boyer
Feb 15, 2012·Virchows Archiv : an International Journal of Pathology·Dominique WendumRaoul Poupon

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