Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present

The Open Orthopaedics Journal
Maja Fadzan, Josette Bettany-Saltikov

Abstract

Adolescent idiopathic scoliosis is one of the most common spinal deformities, yet its cause is unknown. Various theories look to biomechanical, neuromuscular, genetic, and environmental origins, yet our understanding of scoliosis etiology is still limited. Determining the cause of a disease is crucial to developing the most effective treatment. Associations made with scoliosis do not necessarily point to causality, and it is difficult to determine whether said associations are primary (playing a role in development) or secondary (develop as a result of scoliosis). Scoliosis is a complex condition with highly variable expression, even among family members, and likely has many causes. These causes could be similar among homogenous groups of AIS patients, or they could be individual. Here, we review the most prevalent theories of scoliosis etiology and recent trends in research.

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Citations

Jun 29, 2018·Spine·Jocelyn ComptonStuart Weinstein
Aug 9, 2020·Global Spine Journal·Prudence Wing Hang CheungJason Pui Yin Cheung
Apr 22, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Daniel AddaiAndrew James Bowey
Jan 11, 2021·Medical Hypotheses·Ziyang LiuTie Liu
Apr 30, 2021·Frontiers in Pediatrics·Tong QiuYi Ji

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