Etiologies and Short-Term Mortality in Patients with Ultraelevated Serum Ferritin

Southern Medical Journal
Timothy Beer, Joseph Vadakara

Abstract

Hyperferritinemia is common in states of iron overload, inflammation, and malignancy. There is evidence that higher ferritin levels may be associated with worse outcomes in several clinical conditions. Available data have been drawn primarily from cases of serum ferritin between 1000 and 5000 ng/mL and from relatively few cases of serum ferritin >5000 ng/mL. In addition, most studies have allowed for the assignment of only a single etiology per case of hyperferritinemia, when many cases may result from a combination of multiple etiologies. This study evaluates the distribution of etiologies and short-term mortality in patients with ultrahyperferritinemia (defined as a serum ferritin concentration >5000 ng/mL). We retrospectively identified 405 patients older than 18 years who had serum ferritin concentrations >5000 ng/mL measured within the Geisinger Health System between 2004 and 2014. For each patient, we evaluated demographics, serum ferritin concentration, contributing etiologies, and mortality at 30 days and 6 months following index serum ferritin measurement. Ultrahyperferritinemia was caused by a combination of multiple etiologies in 51% of cases, a single etiology in 44% of cases, and an undetermined etiology in 5% of c...Continue Reading

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Citations

Sep 29, 2017·Current Opinion in Allergy and Clinical Immunology·Christian A Wysocki
Apr 22, 2016·International Urology and Nephrology·Edward J Filippone, John L Farber
Feb 16, 2019·Frontiers in Immunology·Eleni Karakike, Evangelos J Giamarellos-Bourboulis
Nov 14, 2020·Expert Review of Molecular Diagnostics·Evdoxia Kyriazopoulou, Evangelos J Giamarellos-Bourboulis

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