Etiologies of Extreme Thrombocytosis: A Contemporary Series

Mayo Clinic Proceedings
Ronan W HsiehRonald S Go

Abstract

To describe the multifactorial etiologies of extreme thrombocytosis (EXT) in different care settings and the frequency of finding an occult malignancy. We conducted a retrospective chart review at Mayo Clinic from January 1, 2011, through December 31, 2016. Adult patients who had at least 2 readings of platelet counts greater than 1000×109/L within 30 days of each other were included. We determined the causes of EXT on the basis of preset definitions of precipitating factors and identified the dominant causes on the basis of the trend of platelet counts. A total of 44,490 patients had thrombocytosis, and 305 patients (0.7%) had EXT. In 242 patients (79.3%), EXT was multifactorial. Surgical complications (54.1%) and hematologic malignancies (27.9%) were the 2 most dominant causes. Thirty-eight patients (12.5%) had new diagnoses of malignancies, mostly myeloproliferative neoplasms. In inpatients, surgical complications (71.9%), concurrent/previous splenectomy (50.5%), and infections (44.9%) were the most common causes, whereas hematologic malignancies (56.9%), iron deficiency (36.7%), and previous splenectomy (28.4%) were the most common causes in outpatients. Hematologic malignancy was 3.4 times more likely to be the cause of EX...Continue Reading

References

Mar 19, 2004·The New England Journal of Medicine·Andrew I Schafer
Dec 2, 2004·Blood Reviews·Ronald S Go
Oct 4, 2005·British Journal of Haematology·Alexandra P WolanskyjAyalew Tefferi

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Citations

Nov 28, 2019·The New England Journal of Medicine·Ayalew Tefferi, Animesh Pardanani
Mar 16, 2021·American Journal of Hematology·Giuseppe G LoscoccoAlessandro M Vannucchi

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