PMID: 11925775Apr 3, 2002Paper

Etiology and pathogenesis of Alzheimer dementia

Wiener medizinische Wochenschrift
T KratzschL Frölich

Abstract

Alzheimer's disease (AD) is the most common cause of primary dementia, characterized by a progressive process of pathophysiological restructuring of the brain over decades. The hallmark of Alzheimer's disease is the extracellular accumulation and deposition of insoluble amyloid, to be found in the parenchyma in the form of amyloid plaques and in meningeal and cerebral vessels as a congophile angiopathy. Equally conspicuous is the intraneuronal occurrence of neurofibrillary tangles, consisting mainly of hyperphosphorylated tau-protein. Amyloid plaques and neurofibrillary tangles are characteristic, but not specific to Alzheimer's disease. Similar changes can be found in healthy ageing processes and in various other neurodegenerative diseases. It is common to differentiate between an early-onset, familial Alzheimer's disease with an established genetic etiology, representing only about 5% of all cases, and the more typical late-onset, sporadic Alzheimer's disease with an age of onset above 65 years and no clear pattern of inheritance. Although there seems to be a large heterogeneity in the etiology of Alzheimer's disease, the amyloid-cascade-hypothesis has taken a central position as a model for the general etiopathogenesis. The ...Continue Reading

Citations

Jun 10, 2003·Wiener klinische Wochenschrift·Imrich Blasko, Beatrix Grubeck-Loebenstein
Aug 26, 2009·Journal of Molecular Neuroscience : MN·Sandeepta BurgulaSurya S Singh
Nov 23, 2006·Biochimica Et Biophysica Acta·Yi WenJames W Simpkins

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