Etiology and risk factors for meningitis and/or bacteremia after craniotomy for patients with glioma

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Yaning WangWenbin Ma

Abstract

To evaluate the incidence and microbiological profile of meningitis and/or bacteremia after craniotomy in patients with glioma and analyze the risk factors relevant to postoperative meningitis.
 Methods: All demographic data, etiological data and clinical data for hospitalized patients who underwent craniotomy in Dept. of Neurosurgery of Peking Union Medical College Hospital between Jan. 2013 to Dec. 2017 were recorded.
 Results: The incidence of post-craniotomy meningitiswas 7.73%, bacteremia was 2.21% and meningitis combined with bacteremia was 1.10%. The positive rate for cerebrospinal fluid culture was 78.57%. Among the 11 cases of meningitis, 20 bacteria were detected, and the most common gram-positive bacteria were: epidermal Staphylococcus (3 case, 15.0%), and hemolytic Staphylococcus (3 case, 15.0%); the most common gram-negative one was Klebsiella pneumoniae (2 case, 10.0%). Among the 5 cases of bacteremia, Klebsiella pneumoniae was the most common one (3 cases, 60.0%). Most of the gram-positive bacteria were sensitive to vancomycin and were resistant to penicillin G. Most of the gram-negative bacteria were sensitive to the 3rd generation of cephalosporin and meropenem. Among all the 16 patients, 13 were good in progno...Continue Reading

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