PMID: 2485493Mar 1, 1989Paper

Etiology of acute infections of the lower respiratory tract in hospitalized infants: bacterial antigens

Revista chilena de pediatría
F MartínezP Farías

Abstract

Demonstration of bacterial antigens in biological fluids has been used for early detection of bacterial infections. Recent evidence suggests that higher detection rates of these antigens can be obtained from concentrated urine than from serum samples of patients. Evidence of bacterial infection by antigen detection was looked for from 50 fold concentrated urine samples by means of an ultrafilter system (Minicom) and latex agglutination for Haemophilus influenzae B (HiB) and Streptococcus pneumoniae (Sp) in three groups of patients. Group A (Positive controls), included 7 patients whose blood culture were positive for HiB (n = 5) and Sp (n = 2). Group B (Healthy controls) involved 16 children without clinical and laboratory signs of infection, coming from ambulatory well baby clinics and surgical wards, and group C was formed by 77 patients with negative blood cultures but with clinical and X ray evidence of lower respiratory tract infection. The corresponding antigen was demonstrated in urine samples from all group A patients. Three group B subjects gave positive results for HiB antigen. HiB antigen was detected from 10 and Sp antigen from 2 group C patients. These results suggest that the search for bacterial antigens in urine...Continue Reading

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