PMID: 3133164Jul 1, 1988Paper

Etiology of carbon dioxide retention at rest and during exercise in chronic airflow obstruction

R W LightS E Brown


The purpose of this project was to better define factors that influence the resting PaCO2 and the change in the PaCO2 from rest to exercise in patients with moderate to severe chronic airflow obstruction. Pulmonary function testing, symptom-limited exercise tests using arterial catheter lines, and resting ventilatory and mouth occlusion pressure responses to hypercapnia and hypoxia were obtained in 19 patients (mean FEV1 = 1.07 +/- .50 L). The resting PaCO2 was closely related to the resting hypercapnic response. The highest correlation coefficient was between the PaCO2 and the ventilation at PCO2 = 60 obtained from the resting hypercapnic response (r = -0.74, p less than 0.001). A higher PaCO2 also tended to occur in patients with a lower FEV1 and a lower PaO2. The resting PaCO2 was not correlated significantly with the VT or the VD/VT. The change in the PaCO2 from rest to exercise was not significantly related to any measure of resting hypercapnic or hypoxic response, but rather was most dependent on the ventilatory response to exercise (delta VE/delta VCO2). Patients with a lower FEV1 or smaller decreases in the PaO2 with exercise tended to have larger increases in PaCO2 with exercise. The delta VE/delta VCO2 was higher in t...Continue Reading


Dec 15, 1978·Pflügers Archiv : European journal of physiology·F SaibeneR Mostardi
Dec 1, 1976·Clinical Science and Molecular Medicine·G W Bradley, R Crawford
Jul 11, 1968·The New England Journal of Medicine·R V Lourenço, J M Miranda
Aug 1, 1981·The American Journal of Medicine·S JavaheriH Kazemi


Aug 6, 2002·Respiratory Physiology & Neurobiology·Duncan L Turner, D Paul Sumners
Jun 1, 1993·The American Review of Respiratory Disease·C A Vaz Fragoso, M A Miller
Mar 5, 2003·Clinics in Sports Medicine·Jonathon Truwit
Feb 1, 2013·Pulmonary Medicine·Ioannis VogiatzisVasileios Andrianopoulos
Aug 16, 2011·Respiratory Physiology & Neurobiology·Patrizia PaolettiPaolo Palange

Related Concepts

Carbon Dioxide
Lung Diseases, Obstructive
Lung Volume Measurements
Pulmonary Gas Exchange
Ventilation-Perfusion Ratio

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