Etiology of diarrhea among children under the age five in China: Results from a five-year surveillance

The Journal of Infection
Jianxing YuW Yang

Abstract

Diarrhea is a leading cause of morbidity and mortality for children, although sparse data is available on the etiology of diarrhea in China. This study was conducted to determine main causes that underlie childhood diarrhea and related diseases. Surveillance data for diarrhea was collected from 213 participating hospitals between 2009 and 2013. These stool specimens, from children aged 0-59 months, were then analyzed for a panel of etiological agents consisting of 5 viruses, 8 bacteria and 3 protozoa. The proportion of children who tested positive for each pathogen was calculated and seasonal patterns for major organisms were determined. Pathogens were identified in 44.6% of the 32,189 samples from children with diarrhea. The most commonly detected pathogens were rotavirus (29.7% of cases), norovirus (11.8%), Diarrheagenic Escherichia coli (DEC; 5.0%), adenovirus (4.8%), non-typhoidal Salmonella (NTS; 4.3%), and Shigella spp. (3.6%). A strong seasonal pattern was observed for these organisms, including rotavirus (winter), norovirus (autumn), and DEC, NTS, and Shigella (summer). A wide range of enteropathogens were detected in this five-year surveillance study; rotavirus and norovirus were most common among children under the ag...Continue Reading

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Citations

Jan 14, 2016·Global Public Health·Ahmad KomarulzamanEelke de Jong
Jun 29, 2016·Infectious Diseases of Poverty·Shun-Xian ZhangXiao-Nong Zhou
Sep 25, 2016·BMC Infectious Diseases·Shun-Xian ZhangXiao-Nong Zhou
Jul 8, 2016·Environmental Science. Processes & Impacts·Timothy R Julian
Feb 9, 2017·The Pediatric Infectious Disease Journal·Hailing ChangMei Zeng
May 11, 2016·The Pediatric Infectious Disease Journal·Zheng HuangXuebin Xu
Nov 18, 2016·Frontiers in Cellular and Infection Microbiology·Xiangning BaiYanwen Xiong
Jan 19, 2017·Emerging Infectious Diseases·Jianxing YuZhongjie Li
Apr 24, 2020·Heliyon·Harriet U UgbokoJohn O Oyewale
Apr 9, 2021·PloS One·Hailing ChangMei Zeng
May 1, 2021·Nature Communications·Li-Ping WangUNKNOWN Chinese Centers for Disease Control and Prevention (CDC) Etiology of Diarrhea Surveillance Study Team

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