Etiology of Diarrhea Among Hospitalized Children in Blantyre, Malawi, Following Rotavirus Vaccine Introduction: A Case-Control Study.

The Journal of Infectious Diseases
Miren Iturriza-GómaraNigel A Cunliffe

Abstract

Despite rotavirus vaccination, diarrhea remains a leading cause of child mortality. We collected stool specimens from 684 children <5 years of age hospitalized with diarrhea (cases) and 527 asymptomatic community controls for 4 years after rotavirus vaccine introduction in Malawi. Specimens were tested for 29 pathogens, using polymerase chain reaction analysis. Three or more pathogens were detected in 71% of cases and 48% of controls. Pathogens significantly associated with diarrhea included rotavirus (in 34.7% of cases and 1.5% of controls), enteric adenovirus (in 29.1% and 2.7%, respectively), Cryptosporidium (in 27.8% and 8.2%, respectively), heat-stable enterotoxin-producing Escherichia coli (in 21.2% and 8.5%, respectively), typical enteropathogenic E. coli (in 18.0% and 8.3%, respectively), and Shigella/enteroinvasive E. coli (in 15.8% and 5.7%, respectively). Additional interventions are required to prevent diarrhea due to rotavirus and other common causal pathogens.

References

Mar 22, 2013·The New England Journal of Medicine·Daniel C PayneUmesh D Parashar
Aug 7, 2013·Journal of Medical Virology·Eamonn TrainorNigel Cunliffe
Jun 3, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James A Platts-MillsEric R Houpt
Sep 15, 2017·Journal of Pediatric Gastroenterology and Nutrition·Aldo A M LimaRichard L Guerrant
Jan 23, 2018·Journal of Pediatric Gastroenterology and Nutrition·Aldo A M LimaRichard L Guerrant

❮ Previous
Next ❯

Citations

Mar 4, 2020·The Journal of Infectious Diseases·Michelle J Groome, Roger I Glass
Aug 11, 2020·Current Opinion in Infectious Diseases·Benjamin LeeJames A Platts-Mills
Mar 3, 2021·PLoS Neglected Tropical Diseases·Drew CaponeJoe Brown
Mar 12, 2021·PLoS Neglected Tropical Diseases·Paul G AshigbiePaul Kelly
Apr 5, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Melina HeinemannChristof D Vinnemeier
May 5, 2021·Microbial Genomics·George E StenhouseKate S Baker
Jul 29, 2021·Microbiology Spectrum·Maria Antonia De FrancescoArnaldo Caruso
Jul 31, 2021·PLoS Neglected Tropical Diseases·Pui-Ying Iroh TamJames Nyirenda

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

R
attribrisk

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revista de saúde pública
Instituto Adolfo Lutz e Centro de Vigilância Epidemiológica Professor Alexandre Vranjac
Current Problems in Pediatrics
T Belhorn
Advances in Virus Research
H Tao
Salud pública de México
Umesh D Parashar, Jacqueline E Tate
The New England Journal of Medicine
D A SackR E Black
© 2022 Meta ULC. All rights reserved