Etiology, prognosis, and hemostatic function after cerebral infarction in young adults

Stroke; a Journal of Cerebral Circulation
A M ChancellorJ Smith

Abstract

We retrospectively evaluated 66 patients younger than 40 years of age who presented with acute nonhemorrhagic cerebral infarction (n = 63) or transient ischemic attacks (n = 3) to determine the possible etiology and long-term outcome at a mean follow-up interval of 3 years after initial presentation. A probable cause for the stroke was identified in 24 patients (36%); this group included one woman with a history of recurrent spontaneous abortions and a positive test for the presence of the lupus anticoagulant. We performed detailed hemostatic investigations at follow-up in 38 (90%) of the remaining 42 patients in whom the cause of the stroke was unknown or uncertain; results of the basic hemostatic screening tests (including that for fibrinogen) were uniformly normal. All 38 patients demonstrated a normal fibrinolytic response as measured by tissue plasminogen activator release to a standard venous occlusion stress test; concentration of the inhibitor of tissue plasminogen activator was not increased. No abnormalities in the concentrations of the inhibitory proteins C or S or antithrombin III were identified, and none of the 38 patients had evidence of a lupus anticoagulant. Neurologic recovery was complete or the residual disa...Continue Reading

References

Apr 1, 1975·Thrombosis Research·O R OdegardU Abildgaard
Sep 1, 1978·British Journal of Haematology·T ExnerH Kronenberg
Jan 1, 1978·Stroke; a Journal of Cerebral Circulation·A B GrindalJ R Taylor
Feb 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·S C SharmaM L Suri
May 1, 1978·American Heart Journal·P O EttingerT J Regan
Feb 1, 1977·Acta Neurologica Scandinavica·B Hindfelt, O Nilsson
Feb 1, 1977·Acta Neurologica Scandinavica·B Hindfelt, O Nilsson
Jul 7, 1977·The New England Journal of Medicine·P MillsE Craige
Jan 1, 1975·Archives of Neurology·Z KalendovskyP Steele
Jun 22, 1985·Lancet·D Hilton-Jones, C P Warlow
Jul 2, 1988·Lancet·M W WebsterG L Glasgow
Oct 1, 1987·The Journal of Pediatrics·S J Israels, S S Seshia
Aug 1, 1986·Archives of Neurology·N F Tabachnik-Schor, S A Lipton
Aug 1, 1987·Annals of Neurology·M Natowicz, R I Kelley
May 5, 1988·The New England Journal of Medicine·P LechatY Grosgogeat
Aug 1, 1986·Thrombosis Research·J L Martinoli, K Stocker
May 1, 1987·Archives of Neurology·J Bogousslavsky, F Regli
Oct 15, 1987·The New England Journal of Medicine·J MiletichG Broze
Aug 1, 1986·Archives of Neurology·H P AdamsG J Toffol
Oct 23, 1986·The New England Journal of Medicine·P A Wolf
Nov 1, 1986·Annals of Internal Medicine·J R HarveyU Thadani
Nov 9, 1985·British Medical Journal·M R Wilkins, M J Kendall
Jul 27, 1968·British Medical Journal·J N CrossW B Jennett
Jan 24, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·B WimanM Rånby
Dec 13, 1984·The New England Journal of Medicine·P C Comp, C T Esmon
Jan 1, 1983·Stroke; a Journal of Cerebral Circulation·R G Hart, V T Miller
May 1, 1983·Stroke; a Journal of Cerebral Circulation·G LandiL Candelise
Aug 1, 1984·American Journal of Epidemiology·R BonitaJ D North
Jan 1, 1984·Headache·L J Spaccavento, G D Solomon
May 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·G M Klein, T P Seland
Nov 1, 1981·The Journal of Clinical Investigation·J H GriffinC Wideman
Sep 17, 1981·The New England Journal of Medicine·B V Stadel
Jun 1, 1981·Acta Neurologica Scandinavica·L TengbornI M Nilsson
Jan 17, 1980·The New England Journal of Medicine·H J BarnettP M Nichol
Feb 1, 1980·Annals of Internal Medicine·J R MuehS I Rapaport
Feb 3, 1955·The New England Journal of Medicine·L BERLINH L MARTIN
Dec 1, 1960·Brain : a Journal of Neurology·J G HUMPHREY, T H NEWTON

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Citations

Jan 13, 2005·Journal of Neurology·J F VaronaJ A Molina
Sep 1, 1996·Journal of the Neurological Sciences·T Tatlisumak, M Fisher
Dec 16, 2006·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Marina CaoMaurizia Rasura
Jan 13, 2001·Clinical Neurology and Neurosurgery·M AmiriS M Nazarian
Apr 13, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·N VilaA Chamorro
Oct 19, 2006·Pediatric Emergency Care·Sunit P JariwalaSudipta Roychowdhury
Dec 9, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H Naess, U Waje-Andreassen
Aug 1, 1993·Archives of Disease in Childhood·C R Kennedy
Jan 5, 2011·Stroke Research and Treatment·Jose F Varona
Jul 21, 2010·Neurology India·Kameshwar Prasad, Kapil K Singhal
Mar 3, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rosalba PatellaMaurizia Rasura
Jan 1, 1990·Annals of Medicine·M Hillbom, M Kaste
Jun 20, 2014·Annals of the Rheumatic Diseases·Savino SciasciaUNKNOWN APS Action
Jul 1, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Fabio Silvio TacconeSerge A Blecic
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·M Hoffmann
Aug 1, 1997·Emergency Medicine Clinics of North America·S A StahmerD I Mines
Sep 2, 2000·Journal of Autoimmunity·M Petri
Oct 19, 2014·Neuroradiology·Luca SabaMax Wintermark
Jul 10, 2004·Acta Neurologica Scandinavica·H NaessK-M Myhr
Aug 1, 1993·Archives of Disease in Childhood·H Holmes
Aug 1, 1995·Developmental Medicine and Child Neurology·C R KennedyM Chisholm

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