Etiopathogenesis of hemolytic reactions in total artificial heart recipients

Artificial Organs
J Vasků, P Urbánek

Abstract

Hemolysis in total artificial heart (TAH) recipients was analyzed. From a total of 66 long-term experiments lasting from 30-314 days performed in the Brno Research Center, in 53 animals, the total red blood cell (RBC) count, hematocrit, total hemoglobin, and free plasma hemoglobin were investigated. We could essentially divide the whole group of calves in 2 subgroups. The first subgroup was calves with hemolytic reactions, and the second subgroup was calves without any hemolytic reaction at all. In the first subgroup, hemolysis occurred in 47% of the overall number of animals during extracorporeal circulation (ECC), in 15% during ECC and later periodically during the experiment, in 8% during ECC and then continuously during the experiment, and finally in 10% not during ECC but repeatedly during the experiment. In 20% of the animals from the overall number, hemolysis did not occur at all (second subgroup). These results testify to the great individual differences within 1 breed (Bohemian with a substantial component of Holstein). These differences are further modified by exogenous and endogenous factors. First, the inborn resistance of the RBC membrane and also thrombi formation and the mineralization of the driving diaphragm ar...Continue Reading

References

Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·J A VelkerE C Lynch
Jul 1, 1988·Journal of Clinical Immunology·S R WellhausenW C DeVries
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Oct 9, 1969·The New England Journal of Medicine·M C Brain
Oct 5, 1971·Biomedizinische Technik. Biomedical Engineering·C KramerW Bleifeld
Aug 17, 1940·British Medical Journal·N H Fairley

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