Etomidate exposure in early infant mice (P10) does not induce apoptosis or affect behaviour

Acta Anaesthesiologica Scandinavica
Y NymanH Viberg

Abstract

Numerous animal studies have shown that all commonly used intravenous anaesthetic drugs and volatile agents may cause neuronal apoptosis following exposure in early life. Most studies have focussed on detecting increased apoptosis but their methods are not always readily transferrable to humans. The lipid formulation of etomidate represents an alternative to the currently established intravenous anaesthetic agents but there is no animal or human data on apoptosis or long-term behavioural changes. The aim of our study was to investigate the effects of etomidate on cerebral neuronal apoptosis and long-term behavioural effects using an established mouse model that represents the clinically relevant period of anaesthesia during early infancy in humans. Six groups of 10 day old mice (P10) were injected with either etomidate 0.3, 3 or 10 mg/kg, propofol 60 mg/kg, ketamine 50 mg/kg or placebo only. Apoptosis in the cerebral cortex and hippocampus was assessed 24 h after treatment (activated caspase-3). Late behavioural effects were tested at 2 months of age (spontaneous activity in a new environment). No evidence was found of differences in activated caspase 3-concentrations among the study groups. Significant late behavioural changes...Continue Reading

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Citations

Oct 22, 2016·Journal of Neurosurgical Anesthesiology·William M JacksonCyrus D Mintz
Jul 18, 2019·Critical Reviews in Toxicology·Luís FélixLuís Antunes
Jul 18, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Bruno Coêlho CavalcantiManoel Odorico de Moraes
Aug 18, 2020·Brain Research Bulletin·Fan YangHongtao Liu

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis