PMID: 8610640Apr 1, 1996Paper

Etoposide-cisplatin and thoracic radiation therapy salvage of incomplete responders to a noncisplatin induction regimen for limited and extensive small-cell carcinoma of the lung

American Journal of Clinical Oncology
E G ShawR E Lee

Abstract

Our purpose was to determine the ability of an etoposide-cisplatin (EP )-based regimen to salvage patients with limited and extensive small-cell lung cancer who are incomplete responders to cyclophosphamide-Adriamycin-vincristine-etoposide (CAVE) chemotherapy, and to determine the ability of thoracic radiation therapy (TRT) to salvage CAVE and EP incomplete responders. Fifty-eight patients with small-cell lung cancer (33, limited disease; 25, extensive disease) were entered on this Phase II study between November 1984 and December 1987. Patients received three cycles of CAVE chemotherapy, followed by two cycles of CEPi (cyclophosphamide-etoposide-cisplatin (infusional) and two cycles of CE (cyclophosphamide-etoposide) in conjunction with TRT and prophylactic cranial irradiation (PCI). The overall response rate to CAVE was 62% [5% complete response (CR), 57% partial response (PR) + regression (REGR)]. Of the patients who failed to achieve a CR with CAVE, 81% responded to CEPi (44% CR, 36% PR). Of the patients who did not achieve a CR with either CAVE or CEPi, 89% responded to TRT (65% CR, 24% PR + REGR). For the 33 patients with limited disease, the median survival time and 2-year survival rate were 16.1 months and 24%, respecti...Continue Reading

References

Jan 1, 1989·Seminars in Surgical Oncology·T J Dougherty
Nov 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A PerezG Omura
Dec 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R JettJ W Kugler
Feb 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N MurrayP Dixon

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