ETS2 is a prostate basal cell marker and is highly expressed in prostate cancers aberrantly expressing p63

The Prostate
Alba TorresTamara L Lotan

Abstract

Rare prostate carcinomas aberrantly express p63 and have an immunophenotype intermediate between basal and luminal cells. Here, we performed gene expression profiling on p63-expressing prostatic carcinomas and compared them to usual-type adenocarcinoma. We identify ETS2 as highly expressed in p63-expressing prostatic carcinomas and benign prostate basal cells, with lower expression in luminal cells and primary usual-type adenocarcinomas. A total of 8 p63-expressing prostate carcinomas at radical prostatectomy were compared to 358 usual-type adenocarcinomas by gene expression profiling performed on formalin fixed paraffin embedded tumor tissue using Affymetrix 1.0 ST microarrays. Correlation between differentially expressed genes and TP63 expression was performed in 5239 prostate adenocarcinomas available in the Decipher GRID. For validation, ETS2 in situ hybridization was performed on 19 p63-expressing prostate carcinomas and 30 usual-type adenocarcinomas arrayed on tissue microarrays (TMA). By gene expression, p63-expressing prostate carcinomas showed low cell cycle activity and low Decipher prognostic scores, but were predicted to have high Gleason grade compared to usual-type adenocarcinomas by gene expression signatures and...Continue Reading

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Citations

Sep 7, 2019·Nutrients·Avinash KumarAnait S Levenson
Feb 27, 2020·Archives of Pathology & Laboratory Medicine·Jenny RossXiming J Yang
Sep 5, 2019·Asian-Australasian Journal of Animal Sciences·Dongjiao NiXinhua Zou
Oct 11, 2020·Virchows Archiv : an International Journal of Pathology·Michaela GaloczovaPhilip J Coates
Jul 20, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Mirazkar D PandareeshKullaiah Byrappa

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