ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis

Breast Cancer Research : BCR
Mandy DumortierAnne Chotteau-Lelievre

Abstract

The ETS transcription factor ETV4 is involved in the main steps of organogenesis and is also a significant mediator of tumorigenesis and metastasis, such as in breast cancer. Indeed, ETV4 is overexpressed in breast tumors and is associated with distant metastasis and poor prognosis. However, the cellular and molecular events regulated by this factor are still misunderstood. In mammary epithelial cells, ETV4 controls the expression of many genes, MMP13 among them. The aim of this study was to understand the function of MMP13 during ETV4-driven tumorigenesis. Different constructs of the MMP13 gene promoter were used to study the direct regulation of MMP13 by ETV4. Moreover, cell proliferation, migration, invasion, anchorage-independent growth, and in vivo tumorigenicity were assayed using models of mammary epithelial and cancer cells in which the expression of MMP13 and/or ETV4 is modulated. Importantly, the expression of MMP13 and ETV4 messenger RNA was characterized in 456 breast cancer samples. Our results revealed that ETV4 promotes proliferation, migration, invasion, and anchorage-independent growth of the MMT mouse mammary tumorigenic cell line. By investigating molecular events downstream of ETV4, we found that MMP13, an e...Continue Reading

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Citations

Mar 2, 2019·Critical Reviews in Clinical Laboratory Sciences·Stella K Vasiliou, Eleftherios P Diamandis
May 19, 2019·G3 : Genes - Genomes - Genetics·Barbara KlotzManfred Schartl
Sep 27, 2019·Experimental and Therapeutic Medicine·Haibo LiuJian Wang
Nov 21, 2020·Annals of Surgical Oncology·Shohei YoshiyaMasaki Mori
Dec 9, 2020·International Journal of Molecular Sciences·Nam Ji SungSin-Aye Park
Jul 1, 2019·G3 : Genes - Genomes - Genetics·Barbara KlotzManfred Schartl
May 18, 2021·Molecular Therapy. Methods & Clinical Development·Yi LiuXueqiong Zhu
Aug 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Wanfu WuJan-Ake Gustafsson
Jul 16, 2019·The Journal of Physical Chemistry Letters·Jian-Qiang ChenCalvin Yu-Chian Chen

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Methods Mentioned

BETA
PCR
immunoprecipitation
transfection
biopsy
ChIP

Software Mentioned

ImageJ
ZEN Blue

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