Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney

Nutrients
Moon Ho DoSang Keun Ha

Abstract

Eucommia ulmoides Oliv. (EU), also known as Du-Zhong, is a medicinal herb commonly used in Asia to treat hypertension and diabetes. Despite evidence of the protective effects of EU against diabetes, its precise effects and mechanisms of action against advanced glycation end-products (AGEs) are unclear. In this study, we evaluated the effects of EU on AGEs-induced renal disease and explored the possible underlying mechanisms using streptozotocin (STZ)-induced diabetic mice. STZ-induced diabetic mice received EU extract (200 mg/kg) orally for 6 weeks. EU treatment did not change blood glucose and glycated hemoglobin (HbA1c) levels in diabetic mice. However, the EU-treated group showed a significant increase in the protein expression and activity of glyoxalase 1 (Glo1), which detoxifies the AGE precursor, methylglyoxal (MGO). EU significantly upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) expression but downregulated that of receptor for AGE (RAGE). Furthermore, histological and immunohistochemical analyses of kidney tissue showed that EU reduced periodic acid-Schiff (PAS)-positive staining, AGEs, and MGO accumulation in diabetic mice. Based on these findings, we concluded that EU ameliorated the renal damage in di...Continue Reading

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraM Steffes
Feb 14, 1998·Kidney International·T MiyataK Kurokawa
Aug 24, 2000·Journal of Agricultural and Food Chemistry·G C Yen, C L Hsieh
Dec 4, 2003·Bioorganic & Medicinal Chemistry·Hisashi MatsudaMasayuki Yoshikawa
Dec 29, 2004·Diabetes Research and Clinical Practice·Mi-Kyung LeeMyung-Sook Choi
Aug 4, 2007·Kidney International. Supplement·E Schleicher, U Friess
Jan 31, 2008·European Journal of Pharmacology·Lei JinYong-Ping Xu
Jul 5, 2008·Journal of Medicinal Food·Rebecca P DearloveJames L Hargrove
Apr 16, 2010·Kidney International·Detlef Schlöndorff
Jul 24, 2010·European Journal of Clinical Investigation·Martin BuschGunter Wolf
Jan 3, 2013·Diabetes, Obesity & Metabolism·L EngelenC G Schalkwijk
Dec 21, 2013·Diabetes·Naila Rabbani, Paul J Thornalley
Jan 1, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Young Sook KimJin Sook Kim
Mar 19, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Varun Parkash SinghAmteshwar Singh Jaggi
Apr 8, 2014·Chemical Communications : Chem Comm·M KamalovM A Brimble
Apr 25, 2014·Biological & Pharmaceutical Bulletin·Ji-Young LeeKwang-Won Lee
Sep 23, 2014·Molecular Nutrition & Food Research·Dina ZhuWensheng Zhang
Mar 19, 2015·Biomolecules·Kerstin NowotnyTilman Grune
Mar 31, 2015·Clinical Science·Dionne E M MaessenCasper G Schalkwijk
Aug 28, 2015·Journal of the American Society of Nephrology : JASN·Andréa E M StinghenAgnès Boullier
Dec 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shingo HosooKozo Nakamura
Apr 5, 2016·Drug Design, Development and Therapy·Ho-Shan NiuJuei-Tang Cheng
Jun 17, 2016·Glycoconjugate Journal·Brett J WestC Jarakae Jensen
Sep 17, 2016·Medicinal Research Reviews·Paulo MatafomeRaquel Seiça
Jan 6, 2017·Oncotarget·Raffaella Mastrocola

❮ Previous
Next ❯

Citations

Mar 13, 2019·The American Journal of Chinese Medicine·Chao-Yong WangYuan-Zhong Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
electrophoresis
ELISA

Software Mentioned

GraphPad Prism
GraphPad
CaseViewer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.