Eudragit RL100 nanoparticle system for the ophthalmic delivery of cloricromene

The Journal of Pharmacy and Pharmacology
Claudio BucoloRosario Pignatello

Abstract

A Eudragit RL100 polymer nanoparticle system loaded with cloricromene was prepared and characterized on the basis of physicochemical properties, stability and drug release features. To investigate the ocular bioavailability of cloricromene after inclusion in the polymer matrix, the new nanoparticle system was topically administered in the rabbit eye and compared with an aqueous solution of the same drug. The nanoparticle system showed interesting size distribution and surface charge values, suitable for ophthalmic application. The results indicated that the dispersion of cloricromene within Eudragit RL100 polymer nanoparticles increased its ocular bioavailability and enhanced the biopharmaceutical profile. The new cloricromene-loaded nanoparticle system described here may be useful in clinical practice.

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Citations

Feb 16, 2010·Pharmaceutical Research·Esther Eljarrat-BinstockAbraham J Domb
Sep 29, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Khosro AdibkiaAli Nokhodchi
Nov 2, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jenifer Mains, Clive G Wilson
Jul 3, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Takahiro HiraokaTetsuro Oshika
Aug 25, 2007·Nanomedicine·Jo Vandervoort, Annick Ludwig
May 6, 2014·International Journal of Pharmaceutics·Antonio LeonardiRosario Pignatello
Mar 2, 2006·Expert Opinion on Drug Delivery·Deepta Ghate, Henry F Edelhauser
Oct 20, 2012·International Journal of Pharmaceutics·Teresa MusumeciGiovanni Puglisi
May 29, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kris HermansAnnick Ludwig
Jan 19, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Esther Eljarrat-BinstockAbraham J Domb
Jan 16, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Tarl W Prow
Mar 19, 2014·The Journal of Pharmacy and Pharmacology·Joel G SouzaRenata F V Lopez
Jan 10, 2017·Frontiers in Pharmacology·Donatella PaolinoRosario Pignatello
Apr 11, 2017·Advanced Drug Delivery Reviews·Dileep R JanagamTao L Lowe
Mar 23, 2018·Pharmaceutical Development and Technology·Rosario PignatelloTeresa Musumeci
Jul 6, 2004·The Journal of Pharmacy and Pharmacology·Claudio BucoloRosario Pignatello
Oct 5, 2019·Therapeutic Delivery·Pankaj A Jadhav, Adhikrao V Yadav
May 13, 2020·Current Drug Delivery·Sunil Kumar JainKuldeep Rajpoot

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