Eugenol--an inhibitor of lipoxygenase-dependent lipid peroxidation

Prostaglandins, Leukotrienes, and Essential Fatty Acids
K A Naidu

Abstract

The effect of eugenol on enzymatic lipid peroxidation catalyzed by soybean lipoxygenase was studied in an in vitro system. Lipid peroxidation was inhibited by eugenol in a concentration-dependent manner. The half-maximal inhibition (IC50) was found to be 380 microM eugenol. Enzyme kinetic studies showed that eugenol non-competitively inhibited lipid peroxidation by altering the maximum velocity (Vmax) and without any change in Michaelis-Menten constant (Km) values. The inhibitory mechanism implies that eugenol does not inactivate the enzyme directly but may interfere with fatty acid radical intermediates due to its hydroxy radical scavenging ability and thus play a role in inhibiting the propagation of lipid peroxidation.

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Citations

Aug 15, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A SinghR Bamezai
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A SinghR Bamezai
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Dec 24, 2013·The Journal of Pharmacy and Pharmacology·Riyaz MohamedBannikuppe S Vishwanath
May 4, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N Satya PrasadK Akhilender Naidu
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