Eugenol reduces the expression of virulence-related exoproteins in Staphylococcus aureus.

Applied and Environmental Microbiology
Jiazhang QiuXuming Deng

Abstract

Eugenol, an essential oil component in plants, has been demonstrated to possess activity against both gram-positive and gram-negative bacteria. This study examined the influence that subinhibitory concentrations of eugenol may have on the expression of the major exotoxins produced by Staphylococcus aureus. The results from a tumor necrosis factor (TNF) release assay and a hemolysin assay indicated that S. aureus cultured with graded subinhibitory concentrations of eugenol (16 to 128 microg/ml) dose dependently decreased the TNF-inducing and hemolytic activities of culture supernatants. Western blot analysis showed that eugenol significantly reduced the production of staphylococcal enterotoxin A (SEA), SEB, and toxic shock syndrome toxin 1 (the key exotoxins to induce TNF release), as well as the expression of alpha-hemolysin (the major hemolysin to cause hemolysis). In addition, this suppression was also evaluated at the transcriptional level via real-time reverse transcription (RT)-PCR analysis. The transcriptional analysis indicated that 128 microg/ml of eugenol remarkably repressed the transcription of the S. aureus sea, seb, tst, and hla genes. According to these results, eugenol has the potential to be rationally applied o...Continue Reading

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Citations

Feb 3, 2011·Applied Microbiology and Biotechnology·Jiazhang QiuXuming Deng
Feb 5, 2013·European Journal of Medicinal Chemistry·Xiaodi NiuXuming Deng
Jun 8, 2011·Future Medicinal Chemistry·Menachem Shoham
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