Euglycemic hyperinsulinemia alters the response to orthostatic stress in older adults with type 2 diabetes.

Diabetes Care
Kenneth M MaddenGraydon S Meneilly

Abstract

Insulin has opposing influences on blood pressure by simultaneously increasing adrenergic activity and vasodilatating peripheral blood vessels. In this study, we sought to determine whether hyperinsulinemia affects tilt table responses in older adults with type 2 diabetes not complicated by orthostatic hypotension. Twenty-two older adults (mean age 71.7 +/- 1.1) with diet-controlled or oral hypoglycemic drug-controlled type 2 diabetes were recruited. All subjects with orthostatic hypotension, diabetic nephropathy, and sensory neuropathy were excluded. Subjects underwent euglycemic-hyperinsulinemic clamp and placebo "sham clamp" sessions. Sequential euglycemic-hyperinsulinemic clamps were performed for 2 h at 40 mU x m(-2) x min(-1) (low dose) and 2 h at 80 mU x m(-2) x min(-1) (high dose), and each was followed by a head-up tilt table test at 70 degrees C for 10 min. There were no incidents of presyncope during the sham clamp, whereas there were four presyncopal events during both the low-dose and high-dose tilts. Although the low-dose clamp showed no difference in the response between sessions (two-way ANOVA), subjects demonstrated a significantly larger decrease in mean arterial pressure (P = 0.005) and diastolic blood pressu...Continue Reading

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References

Oct 1, 1976·Journal of Applied Physiology·E A McGuireM Berman
Mar 1, 1995·American Journal of Hypertension·G A RongenT Thien
May 1, 1993·Journal of Applied Physiology·K H WesselingJ J Schreuder
Mar 21, 1998·Metabolism: Clinical and Experimental·C J TackP Smits
Oct 29, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M de KanterG Sundkvist
Aug 6, 2000·Stroke; a Journal of Cerebral Circulation·L A LipsitzV Babikian
Mar 7, 2001·Metabolism: Clinical and Experimental·G S MeneillyJ S Floras
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Josephine M EganDariush Elahi
Feb 27, 2003·Blood Pressure Monitoring·Ilja GuelenWillem Jan Bos
May 27, 2003·American Heart Journal·Graciela Aurora RuizRicardo Jorge Gelpi
Nov 23, 2006·Current Diabetes Reports·Aaron I Vinik, Tomris Erbas
Mar 14, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Louise PiloteVicky Tagalakis
Apr 11, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David C W LauUNKNOWN Obesity Canada Clinical Practice Guidelines Expert Panel
Aug 21, 2007·Diabetes Technology & Therapeutics·Jerrold PetrofskyPatricia Apodaca
Oct 2, 2007·The American Journal of Medicine·Vishal Gupta, Lewis A Lipsitz

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Citations

May 1, 2009·Diabetes/metabolism Research and Reviews
May 3, 2016·Journal of Diabetes and Its Complications·Mark Stecker, Matthew Stevenson
Jul 21, 2015·Journal of the American Geriatrics Society·Kenneth M MaddenGraydon S Meneilly
Apr 1, 2011·Autonomic Neuroscience : Basic & Clinical·Jean-Christophe Philips, André J Scheen
Jan 22, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Elaine M WolfsonAriella Rojhani
Feb 18, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Kenneth M MaddenGraydon S Meneilly

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