PMID: 6108267Jan 1, 1980

Euhypnos forte, high dose temazepam for resistant insomnia: post-marketing surveillance in 10,057 patients unresponsive to conventional hypnotic dosage

The Journal of International Medical Research
L K Fowler, M Schiller


A post-marketing surveillance study of Euhypnos Forte (temazepam 20 mg) capsules for the treatment of insomnia in 10,057 patients previously unresponsive to other hypnotics given in conventional doses. Patients were prescribed a nightly dose of 40 or 60 mg, but 95% actually took 40 mg. At 2 weeks, 89% of patients found the treatment effective, as did 95% at 3 months. Hangover, severe enough to stop treatment, occurred in less than 3% of patients, and other adverse reactions such as headache, dreams, gastrointestinal disturbance and hangover symptoms were reported by only 6% of patients at 2 weeks and 4% at 3 months. The most common reason for stopping treatment was the patient having no further need for hypnotics. Euhypnos Forte was effective in 88% of 3,800 patients who had found nitrazepam unsatisfactory and 90% of 1,013 patients unresponsive to barbiturates.


Jan 1, 1979·The Journal of International Medical Research·H S Sussman
Jan 1, 1979·The Journal of International Medical Research·C A Moon, M Schiller
Dec 16, 1977·European Journal of Clinical Pharmacology·L M FuccellaG Tognoni
Jan 1, 1977·The Journal of International Medical Research·L K Fowler
Jan 1, 1980·The Journal of International Medical Research·L K Fowler


Jul 1, 1981·Pharmacotherapy·M M Mitler
Sep 1, 1982·Drug Intelligence & Clinical Pharmacy·J C McElnayB Alexander

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Dose-Response Relationship, Drug
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