Eukaryote-specific extensions in ribosomal proteins of the small subunit: Structure and function

Translation
Arnab Ghosh, Anton A Komar

Abstract

High-resolution structures of yeast ribosomes have improved our understanding of the architecture and organization of eukaryotic rRNA and proteins, as well as eukaryote-specific extensions present in some conserved ribosomal proteins. Despite this progress, assignment of specific functions to individual proteins and/or eukaryote-specific protein extensions remains challenging. It has been suggested that eukaryote-specific extensions of conserved proteins from the small ribosomal subunit may facilitate eukaryote-specific reactions in the initiation phase of protein synthesis. This review summarizes emerging data describing the structural and functional significance of eukaryote-specific extensions of conserved small ribosomal subunit proteins, particularly their possible roles in recruitment and spatial organization of eukaryote-specific initiation factors.

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Citations

Aug 20, 2019·International Journal of Biological Macromolecules·Smita P Pilla, Ranjit Prasad Bahadur

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Methods Mentioned

BETA
X-ray
nucleotide exchange
GTPase
acetylation

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