Apr 16, 2016

Lateral genetic transfers between eukaryotes and bacteriophages

BioRxiv : the Preprint Server for Biology
Sarah R Bordenstein, Seth R Bordenstein

Abstract

Viruses are trifurcated into eukaryotic, archaeal and bacterial categories. This domain-specific ecology underscores why eukaryotic genes are typically co-opted by eukaryotic viruses and bacterial genes are commonly found in bacteriophages. However, the presence of bacteriophages in symbiotic bacteria that obligately reside in eukaryotes may promote eukayotic DNA transfers to bacteriophages. By sequencing full genomes from purified bacteriophage WO particles of Wolbachia, we discover a novel eukaryotic association module with various animal proteins domains, such as the black widow latrotoxin-CTD, that are uninterrupted in intact bacteriophage genomes, enriched with eukaryotic protease cleavage sites, and combined with additional domains to forge some of the largest bacteriophage genes (up to 14,256 bp). These various protein domain families are central to eukaryotic functions and have never before been reported in packaged bacteriophages, and their phylogeny, distribution and sequence diversity implies lateral transfer from animal to bacteriophage genomes. We suggest that the evolution of these eukaryotic protein domains in bacteriophage WO parallels the evolution of eukaryotic genes in canonical eukaryotic viruses, namely tho...Continue Reading

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Mentioned in this Paper

Latrodectus mactans
Latrodectus tredecimguttatus
Protein Biosynthesis Pathway
Carboxy-Terminal Amino Acid
Virus
Genome
Genes
Attachment Sites, Microbiological
Latrodectus variolus
Peptide Hydrolases

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