Eukaryotic chemotaxis.

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Wouter-Jan Rappel, William F Loomis

Abstract

During eukaryotic chemotaxis, external chemical gradients guide the crawling motion of cells. This process plays an important role in a large variety of biological systems and has wide ranging medical implications. New experimental techniques including confocal microscopy and microfluidics have advanced our understanding of chemotaxis while numerical modeling efforts are beginning to offer critical insights. In this short review, we survey the current experimental status of the field by dividing chemotaxis into three distinct "modules": directional sensing, polarity and motility. For each module, we attempt to point out potential new directions of research and discuss how modeling studies interact with experimental investigations.

References

Jul 1, 1991·Biophysical Journal·P A DiMillaD A Lauffenburger
Jan 1, 1988·Annual Review of Cell Biology·P N Devreotes, S H Zigmond
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·S van Es, P N Devreotes
Dec 26, 2001·Biophysical Journal·Andre Levchenko, Pablo A Iglesias
Jun 14, 2002·Developmental Cell·Alex SobkoRichard A Firtel
Jun 14, 2002·Cell·Frank I Comer, Carole A Parent
Jun 14, 2002·Cell·Miho Iijima, Peter Devreotes
Jul 20, 2002·The Journal of Biological Chemistry·Hila Rubin, Shoshana Ravid
Aug 29, 2002·The EMBO Journal·Leonard BosgraafPeter J M Van Haastert
Aug 31, 2002·Biophysical Journal·Wouter-Jan RappelWilliam F Loomis
Sep 6, 2002·Nature·Henry R Bourne, Orion Weiner
Feb 26, 2003·Cell·Thomas D Pollard, Gary G Borisy
Apr 4, 2003·The Journal of Biological Chemistry·Peter Devreotes, Chris Janetopoulos
May 2, 2003·International Review of Cytology·Shigehiko Yumura, Taro Q P Uyeda
Jun 13, 2003·Molecular Biology of the Cell·Yi Elaine HuangPeter Devreotes
Jul 31, 2003·Current Opinion in Genetics & Development·Dirk Dormann, Cornelis J Weijer
Aug 2, 2003·Journal of Cell Science·Sylvain Merlot, Richard A Firtel
Sep 4, 2003·Journal of Muscle Research and Cell Motility·David R SollHui Zhang
Sep 19, 2003·Current Biology : CB·Alex Mogilner, George Oster
Nov 5, 2003·Molecular Biology of the Cell·Marten PostmaPeter J M Van Haastert
Dec 10, 2003·Current Opinion in Microbiology·Hazel P Williams, Adrian J Harwood
Dec 13, 2003·Bulletin of Mathematical Biology·Maria E Gracheva, Hans G Othmer
Jan 8, 2004·EMBO Reports·Marten PostmaPeter J M Van Haastert
Jan 9, 2004·Current Biology : CB·Frank Schnorrer, Barry J Dickson
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chris JanetopoulosPablo A Iglesias
Jun 11, 2004·Annual Review of Biochemistry·Susanne M Rafelski, Julie A Theriot
Sep 16, 2004·Nature Reviews. Molecular Cell Biology·Peter J M Van Haastert, Peter N Devreotes
Sep 24, 2004·Current Opinion in Genetics & Development·Alan R Kimmel, Richard A Firtel
Oct 8, 2004·The EMBO Journal·Kyung Chan ParkRichard A Firtel
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Carol L ManahanPeter N Devreotes
Oct 16, 2004·Molecular Biology of the Cell·Susan LeeRichard A Firtel
Nov 10, 2004·The Journal of Cell Biology·Atsuo T SasakiRichard A Firtel
Feb 25, 2005·Molecular Biology of the Cell·Scott A MyersChang Y Chung
May 10, 2005·Biophysical Journal·A Mogilner, B Rubinstein
May 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stefan DiezTill Bretschneider

❮ Previous
Next ❯

Citations

Oct 1, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Monica SkogeWouter-Jan Rappel
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jonathan E Phillips, Richard H Gomer
Jul 9, 2011·PLoS Computational Biology·Inbal HechtWouter-Jan Rappel
Oct 30, 2009·Current Opinion in Microbiology·Nick D ReadAndrew B Goryachev
Jun 13, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Changji Shi, Pablo A Iglesias
Feb 10, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Erik S Welf, Jason M Haugh
Jan 25, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andrew B GoryachevNick D Read
Nov 27, 2015·Developmental Cell·Allison W McClureDaniel J Lew
Aug 3, 2018·BMC Genomics·Esther RincónSean R Collins
Oct 16, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ganhui Lan
Jun 7, 2011·Journal of Statistical Physics·Bo HuWouter-Jan Rappel
Mar 17, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Bo HuHerbert Levine
Sep 23, 2021·Genome Biology·Pâmela A AlexandreAntonio Reverter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

FEBS Letters
Christopher Janetopoulos, Richard A Firtel
Current Opinion in Cell Biology
Pablo A Iglesias, Peter N Devreotes
Proceedings of the National Academy of Sciences of the United States of America
Herbert LevineWouter-Jan Rappel
© 2021 Meta ULC. All rights reserved