Eukaryotic DNA polymerase ζ

DNA Repair
Alena V Makarova, Peter M Burgers

Abstract

This review focuses on eukaryotic DNA polymerase ζ (Pol ζ), the enzyme responsible for the bulk of mutagenesis in eukaryotic cells in response to DNA damage. Pol ζ is also responsible for a large portion of mutagenesis during normal cell growth, in response to spontaneous damage or to certain DNA structures and other blocks that stall DNA replication forks. Novel insights in mutagenesis have been derived from recent advances in the elucidation of the subunit structure of Pol ζ. The lagging strand DNA polymerase δ shares the small Pol31 and Pol32 subunits with the Rev3-Rev7 core assembly giving a four subunit Pol ζ complex that is the active form in mutagenesis. Furthermore, Pol ζ forms essential interactions with the mutasome assembly factor Rev1 and with proliferating cell nuclear antigen (PCNA). These interactions are modulated by posttranslational modifications such as ubiquitination and phosphorylation that enhance translesion synthesis (TLS) and mutagenesis.

References

Jan 1, 1985·Molecular & General Genetics : MGG·C W LawrenceR B Christensen
Jan 1, 1972·Molecular & General Genetics : MGG·J F Lemontt
Jun 14, 1996·Science·J R NelsonD C Hinkle
Aug 22, 1996·Nature·J R NelsonD C Hinkle
Jan 10, 1997·The Journal of Biological Chemistry·K J GerikP M Burgers
Mar 14, 2000·The Journal of Biological Chemistry·F YuanZ Wang
Oct 26, 2000·Current Biology : CB·J WittschiebenR D Wood
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C W Lawrence, V M Maher
Aug 4, 2001·The Journal of Biological Chemistry·Y MurakumoM Takahashi
Oct 2, 2001·The Journal of Biological Chemistry·P M BurgersR Woodgate
Dec 12, 2001·Mutation Research·K F GrossmannR E Moses
Jun 8, 2002·Biochemical and Biophysical Research Communications·Jiyang O-WangMasatoshi Tagawa
Jan 7, 2003·Genes & Development·Robert E JohnsonLouise Prakash
Oct 1, 2005·Science·Deepak T NairAneel K Aggarwal
Oct 18, 2005·Molecular and Cellular Biology·Narottam AcharyaLouise Prakash
Dec 22, 2005·Nature Structural & Molecular Biology·Francisco J AsturiasErik Johansson
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xinjian LinStephen B Howell
Jul 26, 2006·The Journal of Biological Chemistry·Jerzy MajkaPeter M J Burgers
Sep 15, 2006·Nucleic Acids Research·Xuejun ZhongThomas A Kunkel
Sep 20, 2006·Molecular and Cellular Biology·Caixia GuoErrol C Friedberg
Jul 7, 2007·Science·Zachary F PursellThomas A Kunkel
Aug 24, 2007·DNA Repair·Ayako N SakamotoThomas A Kunkel
Feb 16, 2008·Nucleic Acids Research·Amy L AbdulovicSue Jinks-Robertson

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Citations

Nov 26, 2015·The Journal of Cell Biology·Scott C Rosenberg, Kevin D Corbett
May 5, 2016·American Journal of Medical Genetics. Part a·Markus VogelFanny Kortüm
Jul 1, 2016·Journal of Medicinal Chemistry·Dmitry M Korzhnev, M Kyle Hadden
Aug 3, 2016·Chemical Research in Toxicology·April C L Bostian, Robert L Eoff
Nov 2, 2016·Nucleic Acids Research·Matthew R Northam, Kelly M Trujillo
Dec 16, 2016·Scientific Reports·Emanuela TuminiAndrés Aguilera
Mar 11, 2017·Critical Reviews in Biochemistry and Molecular Biology·Alexandra Vaisman, Roger Woodgate
Aug 17, 2018·Proceedings of the National Academy of Sciences of the United States of America·Alessandro A RizzoDmitry M Korzhnev
Mar 4, 2018·Current Genetics·Anna Bębenek, Izabela Ziuzia-Graczyk
Apr 28, 2019·Genetics·Duyen T Bui, Joachim J Li
Apr 6, 2019·EMBO Reports·Dheva Setiaputra, Daniel Durocher
Nov 19, 2019·Critical Reviews in Biochemistry and Molecular Biology·Yuji Masuda, Chikahide Masutani
Jan 27, 2020·Environmental and Molecular Mutagenesis·Xiaolu MaCaixia Guo
Sep 8, 2019·Current Genetics·Marta A GarbaczThomas A Kunkel
Aug 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Nicolai B LarsenHocine W Mankouri
Jul 30, 2020·The Biochemical Journal·Li FanWei Xiao
Jul 28, 2017·The Journal of Biological Chemistry·Andrey G BaranovskiyTahir H Tahirov
Apr 26, 2020·Nature Communications·Ling LiangYuxin Yin
Aug 19, 2020·Nature Structural & Molecular Biology·Radhika MalikAneel K Aggarwal
Jul 30, 2017·International Journal of Molecular Sciences·Elizaveta O BoldinovaAlena V Makarova
Jul 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Denis A KiktevThomas D Petes
May 21, 2020·Frontiers in Oncology·Martin LiptaySven Rottenberg
Jun 15, 2019·Current Pharmaceutical Design·Daria V KimDmitry O Zharkov
Aug 15, 2019·Nucleic Acids Research·Sara K Martin, Richard D Wood
Sep 19, 2019·Metallomics : Integrated Biometal Science·Paul A Lindahl
Jun 22, 2019·Annual Review of Biochemistry·Jacqueline K BartonElizabeth O'Brien
Oct 28, 2019·Mutagenesis·Roberto Silvestri, Stefano Landi
Jun 23, 2020·Biochemistry. Biokhimii︠a︡·E S ShilkinA V Makarova
Oct 14, 2020·Biochemistry. Biokhimii︠a︡·E S ShilkinA V Makarova
May 14, 2020·DNA Repair·Lindsey J LongMary Ann Osley

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