Eukaryotic initiation factor 4A (eIF4A) during viral infections

Virus Genes
Hilda MonteroClara L Sampieri

Abstract

The helicase eIF4A is part of the cellular eIF4F translation initiation complex. The main functions of eIF4A are to remove secondary complex structures within the 5'-untranslated region and to displace proteins attached to mRNA. As intracellular parasites, viruses regulate the processes involved in protein synthesis, and different mechanisms related to controlling translation factors, such as eIF4A, have been found. The inhibitors of this factor are currently known; these substances could be used in the near future as part of antiviral pharmacological therapies in instances of replication cycles in which eIF4A is required. In this review, the particularities of how some viruses make use of this initiation factor to synthesize their proteins are discussed.

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Citations

May 28, 2020·Cells·Noémie OechslinJérôme Gouttenoire
Feb 17, 2021·Journal of Medicinal Chemistry·Angela Fan, Phillip P Sharp
Apr 4, 2021·International Journal of Molecular Sciences·Olga Sergeeva, Timofei Zatsepin
May 8, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Khadga RajShamsher Singh

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