Eukaryotic systems broaden the scope of synthetic biology.

The Journal of Cell Biology
Karmella A Haynes, Pamela A Silver

Abstract

Synthetic biology aims to engineer novel cellular functions by assembling well-characterized molecular parts (i.e., nucleic acids and proteins) into biological "devices" that exhibit predictable behavior. Recently, efforts in eukaryotic synthetic biology have sprung from foundational work in bacteria. Designing synthetic circuits to operate reliably in the context of differentiating and morphologically complex cells presents unique challenges and opportunities for progress in the field. This review surveys recent advances in eukaryotic synthetic biology and describes how synthetic systems can be linked to natural cellular processes in order to manipulate cell behavior and to foster new discoveries in cell biology research.

References

Nov 1, 1989·Molecular and Cellular Biology·S J Elledge, R W Davis
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·U SträhleG Schütz
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S BraselmannM Busslinger
Feb 5, 2000·Nature·M B Elowitz, S Leibler
Feb 5, 2000·Nature·T S GardnerJ J Collins
Jan 10, 2003·Nucleic Acids Research·Tanja la CourSøren Brunak
Jun 1, 1961·Journal of Molecular Biology·F JACOB, J MONOD
Jun 9, 2004·Nature Biotechnology·Beat P KramerMartin Fussenegger
Jun 12, 2004·EMBO Reports·Christel BoutonnetStéphan Vagner
Feb 22, 2005·Nature Biotechnology·Travis S Bayer, Christina D Smolke
Jul 5, 2005·Nature Reviews. Genetics·Steven A Benner, A Michael Sismour
Nov 25, 2005·Nature·Anselm LevskayaChristopher A Voigt
Nov 25, 2005·Nature·David Sprinzak, Michael B Elowitz
Dec 7, 2005·Journal of Molecular Biology·J Christopher AndersonChristopher A Voigt
Feb 14, 2006·Metabolic Engineering·Wilfried WeberMartin Fussenegger
Mar 30, 2006·The Journal of Gene Medicine·Wilfried Weber, Martin Fussenegger
Jun 2, 2006·Molecular Systems Biology·Ernesto AndrianantoandroRon Weiss
Sep 7, 2006·Bioinformatics·Matthias Heinemann, Sven Panke
Nov 15, 2006·Cellular and Molecular Life Sciences : CMLS·C J WilsonK S Matthews
Feb 10, 2007·Genes & Development·David A DrubinPamela A Silver
Apr 3, 2007·Current Biology : CB·Nicholas T Ingolia, Andrew W Murray
May 23, 2007·Nature Biotechnology·Keller RinaudoYaakov Benenson
Aug 19, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Katsutoshi YokoiPeter A Campochiaro
Aug 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Maung Nyan Win, Christina D Smolke
Sep 19, 2007·Genes & Development·Caroline M Ajo-FranklinPamela A Silver
Oct 20, 2007·Journal of the American Chemical Society·Yoko Nomura, Yohei Yokobayashi
Oct 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Katie BrennerFrances H Arnold
Feb 12, 2008·Trends in Cell Biology·Nicolas Paquin, Pascal Chartrand
Mar 12, 2008·Developmental Cell·Ian A Swinburne, Pamela A Silver
Mar 14, 2008·Chembiochem : a European Journal of Chemical Biology·Takahiro YamauchiNaoki Sugimoto

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Citations

Apr 25, 2012·ACS Synthetic Biology·Karmella A HaynesPamela A Silver
Nov 30, 2011·Nature Reviews. Genetics·Wilfried Weber, Martin Fussenegger
Mar 26, 2011·Molecular BioSystems·Sumitra Shankar, M Radhakrishna Pillai
Jun 15, 2011·The Journal of Biological Chemistry·Karmella A Haynes, Pamela A Silver
May 15, 2012·Nucleic Acids Research·Abhishek GargThomas Z Armel
Jul 4, 2012·Genes & Development·Devin R BurrillPamela A Silver
Oct 28, 2011·Science Translational Medicine·Yvonne Y Chen, Christina D Smolke
Oct 12, 2012·BMC Systems Biology·Carla BosiaMichele Caselle
May 28, 2013·BMC Systems Biology·Mario Andrea MarchisioJörg Stelling
Nov 13, 2010·Journal of Biological Engineering·Francesca CeroniSilvio Cavalcanti
Jul 14, 2010·The Journal of Cell Biology·Priya Prakash Budde, Tom Misteli
Feb 9, 2012·FEBS Letters·Benjamin A BlountTom Ellis
Jun 20, 2012·FEBS Letters·Maximilian Hörner, Wilfried Weber
May 26, 2012·Metabolic Engineering·Chuck Merryman, Daniel G Gibson
Nov 1, 2011·Metabolic Engineering·Patrick M Boyle, Pamela A Silver
Dec 10, 2013·ACS Synthetic Biology·Andreia CarvalhoMark Isalan
Feb 18, 2011·Biotechnology Journal·Anastasia KrivoruchkoJens Nielsen
Mar 17, 2015·ACS Chemical Biology·Guihua ZengFu-Sen Liang
Mar 19, 2011·Cell·Christina D Smolke, Pamela A Silver
Nov 8, 2011·Nature Biotechnology·Andreas Milias-ArgeitisJohn Lygeros
Jun 14, 2017·Nucleic Acids Research·Stefan J Tekel, Karmella A Haynes
May 7, 2015·PloS One·Oleg KanakovMikhail Ivanchenko
Jul 22, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Rafe T Petty, Milan Mrksich

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Methods Mentioned

BETA
nucleotide exchange
nucleotide
GTPase
dissection
transgenic

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