PMID: 8610071Aug 1, 1995Paper

Eumelanin and phaeomelanin contents of human epidermis and cultured melanocytes

Pigment Cell Research
G HuntA J Thody

Abstract

There are two chemically distinct types of melanin: the red-yellow phaeomelanins and the brown-black eumelanins. While both melanins have been detected in human epidermis and cultured melanocytes, it is unknown how the phaeomelanin/eumelanin ratio in human melanocytes maintained in vitro relates to that in the epidermis from which they were isolated. This study uses high-performance liquid chromatography to quantify the eumelanin and phaeomelanin contents of epidermis and/or cultured melanocytes from 12 Europeans with lightly pigmented skin and 9 non-Europeans with more deeply pigmented skin. Epidermis from non-Europeans contained the highest levels of both eumelanin and phaeomelanin and had the lowest phaeomelanin/eumelanin ratios. In contrast, while cultured melanocytes from non-Europeans also had higher levels of eumelanin and phaeomelanin than melanocytes from Europeans, there was no difference in the phaeomelanin/eumelanin ratios in the two groups. However, the phaeomelanin/eumelanin ratios were higher in the cultured melanocytes than in the corresponding epidermis so that while eumelanin was the predominant melanin in these epidermis, phaeomelanin was the major melanin in the cultured melanocytes. These observations may h...Continue Reading

References

Jul 1, 1990·The Journal of Investigative Dermatology·M IwataB B Fuller
Aug 1, 1991·The Journal of Investigative Dermatology·A J ThodyJ M Marks
Apr 1, 1989·The Journal of Investigative Dermatology·P R GordonB A Gilchrest
Jul 1, 1980·The Journal of Investigative Dermatology·G Prota
Dec 1, 1993·The Journal of Investigative Dermatology·V del MarmolG Ghanem
Jun 1, 1993·The Journal of Investigative Dermatology·K IozumiB B Fuller

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Citations

Sep 6, 2001·Journal of Photochemistry and Photobiology. B, Biology·S M De LeeuwA A Schothorst
Nov 28, 2002·Pigment Cell Research·Christine DuvalRainer Schmidt
Feb 15, 2001·The Biochemical Journal·C OlivaresJ C García-Borrón
Feb 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karine RousseauAnne White
Jun 4, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana Luisa KadekaroZalfa A Abdel-Malek
Apr 8, 1999·Pigment Cell Research·S B PotterfV J Hearing
Aug 24, 1999·Pigment Cell Research·U Mårs, B S Larsson
Feb 20, 2008·Photochemistry and Photobiology·Zalfa A Abdel-MalekRenny Starner
Jul 8, 2011·Pigment Cell & Melanoma Research·Daren Low, Ken-Shiung Chen
May 22, 2010·Journal of Clinical Biochemistry and Nutrition·Mika TadaYoshimi Niwano
Sep 15, 2010·Journal of Clinical Biochemistry and Nutrition·Mika TadaYoshimi Niwano
Jul 17, 1998·The Journal of Investigative Dermatology·R SmithJ L Rees
Dec 24, 1997·The Journal of Investigative Dermatology·N P SmitS Pavel
Jul 25, 2008·The Journal of Investigative Dermatology·Anthony L CookRichard A Sturm
Feb 20, 2002·The Journal of Investigative Dermatology·Chunyan ZhaoKari Hemminki
Mar 11, 2004·The Journal of Investigative Dermatology·Hao Ou-YangNikiforos Kollias
Nov 10, 2004·Photodermatology, Photoimmunology & Photomedicine·Eugene Healy
May 17, 2005·Pigment Cell Research·Alison HennessyJonathan Rees
Mar 29, 2003·Veterinary Dermatology·Shola S Sulaimon, Barbara E Kitchell
Jul 11, 2006·Pigment Cell Research·Jennifer E HauserZalfa A Abdel-Malek
Nov 11, 2005·Pigment Cell Research·Albert R Wielgus, Tadeusz Sarna
May 9, 2014·Pigment Cell & Melanoma Research·Jose C García-BorrónCelia Jiménez-Cervantes
Aug 19, 2015·Pigment Cell & Melanoma Research·Sandra Del BinoFrançoise Bernerd
Jan 7, 2014·Journal of the American Academy of Dermatology·Ryan E O'LearyPaul C Levins
Sep 16, 2014·Experimental Dermatology·Ciara HaddadeenEugene Healy
Nov 18, 2003·Annual Review of Genetics·Jonathan L Rees
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Marina TsatmaliAnthony J Thody
Sep 4, 2018·The British Journal of Dermatology·S AlbrechtM C Meinke
Nov 6, 2012·Nature·Mizuho Fukunaga-Kalabis, Meenhard Herlyn
May 31, 2001·The Journal of Biological Chemistry·M FurumuraV J Hearing
Jul 14, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Maja Ann HofmannClaus Garbe

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